Banca de QUALIFICAÇÃO: HERIKS GOMES RIBEIRO
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : HERIKS GOMES RIBEIRO
DATE: 29/08/2023
TIME: 10:00
LOCAL: Link de acesso para videoconferência: meet.google.com/uxy-ufoe-ask
TITLE:
Unraveling the Role of miRNAs as Biomarkers in Chagas Cardiomyopathy: Insights into Molecular Pathophysiology
KEY WORDS:
Chagas cardiomyopathy; miRNA; biomarkers; detection; progression.
PAGES: 90
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Background: Chagas Cardiomyopathy (ChCM) is a severe form of Chagas disease
and a major cause of cardiovascular morbidity and mortality. The dysregulation of the
immune response leads to cardiac remodeling and functional disruptions, resulting in
life-threatening complications. Conventional diagnostic methods have limitations, and
therapeutic response evaluation is challenging. MicroRNAs (miRNAs), important
regulators of gene expression, show potential as biomarkers for diagnosis and
prognosis. Aim: This review aims to summarize experimental findings on miRNA
expression in ChCM and explore the potential of these miRNAs as biomarkers of
Chagas disease. Methods: The search was conducted in the US National Library of
Medicine MEDLINE/PubMed public database using the terms “Chagas
cardiomyopathy” OR "Chagas disease" AND “microRNA” OR “miRNA” OR “miR”.
Additionally, bioinformatics analysis was performed to investigate miRNA-target
interactions and explore enrichment pathways of gene ontology biological processes
and molecular functions. Results: The miR-21, miR-146b, miR-146a, and miR-155
consistently exhibited upregulation, whereas miR-145 was downregulated in ChCM.
These specific miRNAs have been linked to fibrosis, immune response, and
inflammatory processes in heart tissue. Moreover, the findings from various studies
indicate that these miRNAs have the potential as biomarkers for the disease and could
be targeted in therapeutic strategies for ChCM. Conclusion: In this review, we point
out miR-21, miR-146b, miR-146a, miR-155, and miR-145-5p role in the complex
mechanisms of ChCM. These miRNAs have shown as potential biomarkers for precise
diagnosis, reliable prognostic evaluation, and effective treatment strategies in the
ChCM
COMMITTEE MEMBERS:
Externa à Instituição - JULIANA DE ASSIS SILVA GOMES ESTANISLAU - UFMG
Interna - ***.776.184-** - JÉSSICA NAYARA GÓES DE ARAÚJO - UFRN
Presidente - ***.985.294-** - LUCIA MARIA DA CUNHA GALVAO - UFRN