Banca de DEFESA: THAIS DO NASCIMENTO PINHEIRO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : THAIS DO NASCIMENTO PINHEIRO
DATE: 31/01/2023
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/gfj-qfgf-hhz
TITLE:

Sodium Tungstate Dihydrate (Na2WO4·2H2O): A Mild Oxidizing and Efficient Reagent in Organic Synthesis

KEY WORDS:

Nitroxides, Organic Synthesis, Antioxidants, COVID-19, SARS-CoV-2.

PAGES: 74
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Nitroxides are free radicals that have received due attention due to their potential employment as a therapeutic agent, due to their antioxidant properties and low toxicities. Nitroxides react with various oxidants and biological reducers while being recycled in the form of oxal cation and hydroxylamine derivatives. For these reasons, due to promising results in other nitroxide studies, the objective is the synthesis of nitroxide derivatives to be tested as in vitro antioxidants and later evaluated as candidates for covid-19 treatment through infected Vero cell cultures. This work reports the synthesis and identification scheme of compounds: 3,5-dibromo-2,2,6,6- tetramethylpiperidin-4-none (97% yield), 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3- carboxyamide (80% yield), 1-oxi-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3- carboxiamide (42% yield), 1-oxi-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3- carboxylic acid (97% yield), 3-(hydroxymethil)-2,2,5,5-tetramethil-2,5-dihydro-1Hpyrrol-1-oxi (36% yield), (1-oxi-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl) methyl benzensulfonate (26% yield), 3-(azidomethyl)-2,2,5,5-tetramethyl-2,5-dihydro-1Hpyrrol-1-oxi (65% yield), 3,3'-(((1,3-phenylenebis(1H-1,2,3-triazole-4,1-diyl))bis (methylene))bis(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-oxi) (68% yield). The structural characterization of these antioxidants was performed through infrared spectroscopy and the reactions were quite promising by obtaining the planned final product.

COMMITTEE MEMBERS:
Externa à Instituição - JÉSSICA VENÂNCIA FARIA RANGEL - UEA
Presidente - 1571756 - ALESSANDRO KAPPEL JORDAO
Interno - 2276354 - LEANDRO DE SANTIS FERREIRA