Banca de DEFESA: ARTHUR RENAN DE ARAÚJO OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR RENAN DE ARAÚJO OLIVEIRA
DATE: 28/12/2022
TIME: 16:30
LOCAL: Link de acesso para videoconferência: https://meet.google.com/pve-rmad-ora
TITLE:
CIRCULATING ENDOTHELIAL CELL IN PREECLAMPSIA: A SYSTEMATIC
REVIEW AND META-ANALYSES PROTOCOL

KEY WORDS:
Preeclampsia. Circulating endothelial cells. Biomarker. Systematic Review.

PAGES: 136
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Preeclampsia (PE) is a multifactorial and multisystemic disease, whose
pathophysiology involves endothelial injury, increased number of Circulating
Endothelial Cells (CECs) and activation of coagulation. It has as diagnostic
criteria hypertension, which occurs after 20 weeks of gestation, accompanied by
proteinuria and/or target organ dysfunction. PE is associated with several
complications both maternal and fetal, which may culminate in death. Thus, the
identification of biomarkers with diagnostic power can lead to early interventions,
minimizing complications. Some studies have evaluated the association of the
number of CPBs with the development of PE. Thus, the aim of this study was to
investigate whether these cells can be used in the diagnosis of PE. For this, a
systematic review was prepared according to PRISMA guidelines and registered
in PROSPERO (CRD42021226265). PubMed; Lilacs; Scopus; Embase; Web of
Science; Science Direct; Cochrane Library and Gray-literature: CAPES and
Google Scholar, were the databases used to search for articles published until
July 2022, without language restriction. The clinical question was elaborated
according to the PICOT strategy, being eligible observational studies (cross
sectional, case-control and cohort), which evaluated the CPB count in peripheral
blood of pregnant women diagnosed with PE and normotensive women, and the
main outcome was the difference in CPB count between these patients. The
selection by title and abstract, full-text reading, and data extraction steps were
performed by two researchers independently and a third for conflict decision. In
total, 505 articles were retrieved by the search strategy and 6 articles met the
inclusion criteria. The methodological quality of the selected studies was
assessed using the Newcastle-Ottawa scale, and all had a low risk of bias. There
was a statistically significant increase in the CPB count in most studies when
comparing the PE and control groups. Only one study showed that there was no
significant difference. Furthermore, the studies also found a positive correlation
between increased blood pressure and CPB counts. Thus, the SCC count, has
great potential to be used as a new diagnostic biomarker for PE.

COMMITTEE MEMBERS:
Externa à Instituição - ANA PAULA FERREIRA COSTA - UNINASSAU
Interna - ***.474.624-** - KARLA SIMONE COSTA DE SOUZA - UFRN
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Notícia cadastrada em: 12/12/2022 16:34
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