Banca de QUALIFICAÇÃO: MARCIA GABRIELE DE SOUZA JIMENEZ

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARCIA GABRIELE DE SOUZA JIMENEZ
DATE: 28/11/2022
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/set-qwws-wdp
TITLE:

GENOTIPAGEM, CARACTERIZAÇÃO DOS FATORES DE VIRULÊNCIA E PERFIL DE SUSCEPTIBILIDADE ANTIFÚNGICA DE ISOLADOS DE Trichosporon spp. OBTIDOS DE PACIENTES COM PIEDRA BRANCA

KEY WORDS:

Trichosporon, virulence, antifungal susceptibility, genotyping, white piedra

PAGES: 59
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Yeasts belonging to the genus Trichosporon have emerged as emerging pathogens with high morbidity and mortality rates. Primarily, Trichosporon species are etiologic agents of piedra branca, a fungal infection characterized by nodules adhering to the extrafollicular region of the hair shaft. However in recent decades Trichosporon spp. has been considered an opportunistic pathogen responsible for serious infections, especially in immunocompromised patients and those with hematological diseases. The objectives of this study are to determine the production of in vitro virulence factors including; Activity of DNAses, hemolysins and phospholipases, adhesion ability to epithelial cells, cell surface hydrophobicity, melanin production and biofilm production, evaluate fungal growth in the presence of cell wall disruptors viz: Congo Red, Chalcofluor and Sodium Dodecyl Sulfate (SDS), as well as devise an in vitro white piedra infection model and evaluate the antifungal susceptibility profile of clinical isolates of Trichosporon spp. obtained from white piedra patients by comparing them with isolates from systemic infection.

COMMITTEE MEMBERS:
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externa ao Programa - 1801992 - PAULA RENATA LIMA MACHADO - nullExterna ao Programa - 2121234 - VANIA SOUSA ANDRADE - null