Banca de QUALIFICAÇÃO: ARTHUR RENAN DE ARAUJO OLIVEIRA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR RENAN DE ARAUJO OLIVEIRA
DATE: 08/11/2022
TIME: 14:00
LOCAL: Link de acesso para videoconferência: http://meet.google.com/nxs-hcdh-btq
TITLE:
CIRCULATING ENDOTHELIAL CELL IN PREECLAMPSIA: A SYSTEMATIC REVIEW
KEY WORDS:
Preeclampsia. Circulating Endothelial Cells. Biomarker. Systematic Review
PAGES: 124
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Preeclampsia (PE) is a multifactorial disease, whose pathophysiology involves
endothelial damage. Its diagnostic criteria are hypertension, which occurs after
20 weeks of gestation, accompanied by target organ dysfunction. PE is
associated with several complications both maternal and fetal, which may
culminate in death. Thus, the identification of reliable biomarkers with diagnostic
power can lead to early interventions, minimizing complications. Some studies
have evaluated the association of the number of circulating endothelial cells
(CECs) with the development of PE. Thus, the aim of this study is to investigate
the role of CECs in the diagnosis of PE. For this, a systematic review was
prepared according to PRISMA guidelines and registered in PROSPERO
(CRD42021226265). PubMed; Lilacs; Scopus; Embase; Web of Science;
Science Direct; Cochrane Library and Gray-literature: CAPES and Google
Scholar, were the databases used to search for articles published until July 2022
in any language. The clinical question was elaborated according to the PICOT
strategy, being eligible observational studies (cross-sectional, case-control and
cohort), which evaluated the CECs count, in peripheral blood, of pregnant women
diagnosed with PE and normotensive women, being the main outcome the
difference in the SCC count between these patients; studies that did not fit the
inclusion criteria were excluded. The selection step by title and abstract, full text
reading and data extraction were performed by two different researchers and a
third one for conflict decision. A total of 505 articles were retrieved by the search
strategy and 6 articles met the inclusion criteria. The methodological quality of
the selected studies was assessed using the Newcastle-Ottawa Scale, and all
had a low risk of bias. There was a statistically significant difference in CECs
counts in most studies when comparing the PE and control groups and only one
study showed that there was no significant difference. Thus, the CECs count,
has great potential to be used as a new diagnostic biomarker for PE.
COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Interna - ***.474.624-** - KARLA SIMONE COSTA DE SOUZA - UFRN
Externa ao Programa - 010.571.714-25 - SARAH DANTAS VIANA MEDEIROS