Banca de QUALIFICAÇÃO: MARIA CLARA DA CRUZ CARVALHO
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA CLARA DA CRUZ CARVALHO
DATE: 14/06/2022
TIME: 14:30
LOCAL: Link de acesso para videoconferência: https://meet.google.com/bcw-tcjt-gug
TITLE:
Vitamin A and vitamin E in SARS-CoV-2 Infection: An Overview
KEY WORDS:
COVID-19; respiratory infection; retinoic acid; retinol; alpha-tocopherol.
PAGES: 91
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
COVID-19 is a disease caused by SARS-CoV-2, a new coronavirus first identified in Wuhan
(China) and has spread rapidly worldwide, affecting the immune system and causing
exacerbated inflammation. Viral infections can deplete vitamins such as vitamins A and E, and
inadequate nutrient levels can harm health. This study aims to investigate whether COVID-19
affects the levels of these vitamins and how they can help fight the infection. According to the
PRISMA statement, a systematic search was performed using three different databases. The
data from the articles were collected and analyzed by two independent researchers. The quality
of in vivo studies was also assessed. A total of 1,505 articles were retrieved, of which 20 met
the inclusion criteria. Eleven of these articles were in silico and/or in vitro, and nine were in
vivo studies. Adult and elderly patients, including pregnant women with COVID-19, had
decreased vitamin A and E concentrations, below or close to the reference values for
deficiency, but not in children. Supplementation of these vitamins was associated with a better
prognosis. Experimental studies have shown that these vitamins may be targets against SARS
CoV-2 infection, and Retinoic Acid-inducible gene I (RIG-I) has an essential role in combating
the disease by different mechanisms. However, the therapeutic capacity of these vitamins
requires additional biological validation through more robust studies, such as randomized
clinical trials and assessment of food intake of these vitamins. Furthermore, studies that assess
serum levels of these vitamins before infection are also required.
BANKING MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 3218336 - BRUNA ZAVARIZE REIS
Interna - 1055045 - MARCELA ABBOTT GALVAO URURAHY