Microparticles in the development and improvement of pharmaceutical formulations: an analysis of in vivo and in vitro studies
Polymeric microparticles; biological activity; in vitro assay; in vivo assay; drug delivery 19 systems; biological studies
Abstract: Microparticulate systems like microparticles, microspheres, microcapsules or any particle 9 in a micrometer scale (usually of 1-1000 µm) are widely used as drug delivery systems, offering 10 higher therapeutical and diagnostical significance in compare to conventional drug delivery forms. 11 These systems can be manufactured by many raw materials, especially polymers which several have 12 been proved effective to improve the physicochemical properties and biological activities of active 13 compounds. This review will focus on the application in vivo or in vitro in the last decade (2010 to 14 2020) of different active pharmaceutical ingredients microencapsulated in a polymeric or lipid 15 matrices, also the principal formulation factors (excipients and techniques) and mostly the influence 16 on their biological activities with the aim to introduce and discuss the potential applicability of 17 microparticulate systems in the pharmaceutical field.