Banca de QUALIFICAÇÃO: VICTORIA LOUISE PINTO FREIRE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : VICTORIA LOUISE PINTO FREIRE
DATE: 28/03/2022
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/nxr-bzvd-vis
TITLE:

BIOCOMPATIBLE NANOEMULSIONS WITH FITOL FOR TREATMENT AND MONITORING OF LEISHMANIASIS

KEY WORDS:

Nanoemulsions, Leishimaniasis, phytol.

PAGES: 89
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Leishmaniasis is considered one of the main neglected diseases in the world, with large numbers of cases annually, being caused by protozoa of the genus Leishmania spp., it mainly affects populations in poorer countries. The treatment of the disease is very limited, toxic to the patient, expensive and the parasite is resistant to chemotherapy. Thus, in an attempt to minimize the side effects of drugs already in use, reduce drug resistance and improve existing treatments, pharmaceutical nanotechnology emerges with manometric scale drug delivery systems, such as nanoemulsions (NE). NE are oil-inwater or water-in-oil dispersed systems stabilized by surfactants, with nanometric droplet size and can be produced by high or low energy emulsification techniques. Parallel to this, other alternative leishmanicidal active principles have been sought for the treatment of the disease, such as phytol, which is a component of chlorophyll of the diterpene class, which is found abundantly in nature and has a wide range of proven biological activities. Having observed this, the present study aims to develop biocompatible NE using phytol by the phase inversion emulsification technique, a low energy methodology, and subsequently perform in vitro tests in order to verify the toxicity, selectivity and antiparasitic activity of the NEs produced. Therefore, it is expected as a result the development of a new innovative pharmacological alternative to leishmanicide using phytol as the active ingredient.

BANKING MEMBERS:
Presidente - 2276354 - LEANDRO DE SANTIS FERREIRA
Externa ao Programa - 1754360 - WALDENICE DE ALENCAR MORAIS LIMA
Externo à Instituição - ÉVERTON DO NASCIMENTO ALENCAR - UFG