Banca de QUALIFICAÇÃO: ULANA CRISTINA DE ARAUJO TAVARES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ULANA CRISTINA DE ARAUJO TAVARES
DATE: 21/12/2021
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/cre-zgxf-jty
TITLE:

Anti-inflammatory and healing evaluation of chitosan base-films with α, β-amirenone triterpene

KEY WORDS:

Chitosan films; α, β-Amirenone; Physicochemical characterization, healing; in vivo studies.

PAGES: 69
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

α, β-Amirenone is a natural compound of the triterpene class, which has great potential for anti-inflammatory, healing and antimicrobial activity. Chitosan films are increasingly used for topical use because it allows for a gradual release of the drug and many advantages. Thus, the aim of this study is to develop chitosan films incorporating α, β-Amirenone and characterize them, complicating the topical application in the treatment of skin lesions. The α, β-Amirenone (ABAME) systems were given by thermal and non-thermal techniques. The consolidated analysis of the prototype update and an increase in ABAME's thermal stability. The FTIR spectra of the films showed interactions occurring between ABAME and the chitosan matrix. The results of XRD indifferent peaks in halos, characteristic of amorphous compounds, indicate the amorphization of ABAME by chitosan. SEM images elevated the prototype incorporated in the chitosan matrix homogeneously and with partial loss of the crystalline characteristic of pure ABAME. In vivo, it was possible to observe that therapy with films incorporated with ABAME is quite effective, as it has anti-inflammatory properties that help in the healing process of skin lesions, making it possible to evaluate this evolution in a macroscopic, histological and cytokine manner measured in this study.

BANKING MEMBERS:
Externa ao Programa - 1679481 - ANA PAULA BARRETO GOMES
Externa ao Programa - 2374605 - AURIGENA ANTUNES DE ARAUJO
Presidente - 1201781 - FERNANDA NERVO RAFFIN