Banca de DEFESA: MAGNA MARCELA FERREIRA DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MAGNA MARCELA FERREIRA DE OLIVEIRA
DATA : 29/03/2019
HORA: 10:00
LOCAL: SALA 1 DO PPGCF
TÍTULO:

Guidance for Authors on the Preparation and Submission of Manuscripts to Journal of Hypertension

PALAVRAS-CHAVES:

Pre-eclampsia. Extracellular vesicles. Urine. WT-1. Nephrin. Podocin.

PÁGINAS: 72
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Preeclampsia (PE) is a pregnancy-specific disease characterized by hypertension and proteinuria after 20 weeks of gestation, whose complications of PE can directly affect the life of the mother and fetus. Thus, searching for a marker for prediction can lead to earlier intervention in cases of PE. Since the association of podocytes (renal cells) and podocyte marker proteins (Willms tumor factor 1 - WT1, nephrine and podocin) with PE has been described in the literature, it is important to evaluate these proteins in vesicles in the urine (VEus) in this group of patients. Thus, WT-1, nephrine and podocin proteins were investigated in VEus of pregnant women in search of potential markers of preeclampsia using a non-invasively collected sample. Twenty pregnant women, 10 of whom had a diagnosis of preeclampsia (hypertension and proteinuria after 20 weeks gestation) and 10 normotensive women, were included in the study. The proteins were quantified by Western blot after the isolation of the VEs by ultracentrifugation. Significant increase in nephrine (p = 0.008) and was observed in the group patients with preeclampsia when compared to healthy pregnant women. The results suggest that nephrine present in urinary extracellular vesicles, may be a potential marker for the prediction of preeclampsia.

MEMBROS DA BANCA:
Interna - 2323511 - ADRIANA AUGUSTO DE REZENDE
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externo à Instituição - RICARDO NEY OLIVEIRA COBUCCI - UnP