Banca de DEFESA: JOSÉ VENÂNCIO CHAVES JÚNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JOSÉ VENÂNCIO CHAVES JÚNIOR
DATA : 18/03/2019
HORA: 14:00
LOCAL: SALA 2 DO PPGCF
TÍTULO:

A New Ferulic Acid-Nicotinamide Cocrystal With Improved Solubility and Dissolution Performance

PALAVRAS-CHAVES:

cocrystal, ferulic acid, solubility, dissolution profile

PÁGINAS: 185
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The cocrystals are crystalline structures generated from the union of two or more substances in the same crystalline phase, which demonstrate the potential to improve technological and physicochemical parameters related to the pharmaceutical area, for example aqueous solubility, which is a limiting factor on absorption of the drugs administered orally. The ferulic acid (FEA) is a molecule very studied for its antioxidant potential, in which its antitumor results are highlighted, however the low aqueous solubility of this molecule appears as an obstacle to its clinical study. The objective of this work is to develop and characterize physicochemically cocrystals of FEA aiming to improve its aqueous solubility. The cocrystals were prepared by the drying technique under reduced pressure, using ethanol as solvent, and characterized by different analytical techniques: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), nuclear magnetic resonance of hydrogen (NMR-¹H) and scanning electron microscopy (SEM), as well as an experimental planning was developed and the in vitro evaluated. The FEA and nicotinamide cocrystal (CC) presented the best aqueous solubility (70% greater than the isolated FEA). Two methods for quantification of AFE and nicotinamide (NIC) by high performance liquid chromatography, HPLC and UHPLC, were developed and validated. The process of obtaining CC showed good yield (98.3 ± 1.3%) and reproducibility. Analytical techniques provided strong evidence of cocrystal formation between the FEA and the NIC. The experimental design showed the formation of CC in the 1: 1 molar ratio, among the conditions used. The CC showed better dissolution efficiency than the FEA alone in the media of pH 4.5 and 6.8. Considering the need for increasing the bioavailability of the FEA, the developed CC appears as a technological alternative for a more efficient pharmaceutical product for the FEA.

MEMBROS DA BANCA:
Presidente - 1492900 - CICERO FLAVIO SOARES ARAGAO
Externo ao Programa - 2140814 - FERNANDO HENRIQUE ANDRADE NOGUEIRA
Externo à Instituição - FÁBIO SANTOS DE SOUZA - UFPB
Externo à Instituição - RODRIGO MOLINA MARTINS - F.M.Nassau