Banca de QUALIFICAÇÃO: TATIANA XAVIER DA COSTA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : TATIANA XAVIER DA COSTA
DATA : 14/02/2019
HORA: 14:00
LOCAL: SALA 2 DO PPGCF
TÍTULO:

FARMACOCINÉTICA POPULACIONAL DO SULFATO DE MAGNÉSIO NA PRÉ-ECLAMPSIA

PALAVRAS-CHAVES:

Intensive care, Pharmacokinetics, Pre-eclampsia, Magnesium Sulfate.

PÁGINAS: 77
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

INTRODUCTION: Magnesium sulfate is the drug of choice to treat seizures in preeclampsia, despite your extensive use, dosage and great concentration has not been conclusively established. PURPOSE: Developed a population pharmacokinetic (PK) model of magnesium sulfate in preeclampsia and determine key covariates that impact the pharmacokinetics. METHODS: Prospective cohort performed in patients with PE in use of magnesium sulfate from June to February 2016-2018. Serum magnesium concentrations were obtained from 114 patients who received 4 g by injection of magnesium sulfate and subsequent infusion of 10 g in 1 g/h for 24 hours. Maternal blood samples were obtained before administration and after 2, 6, 12 and 18 hours of the initial dose. Population pharmacokinetic parameters of magnesium sulfate (clearance, volume of distribution, time of half life) were estimated using the Monolix software ® 2018 Suite (Lixoft ®, Antony, France). A pharmacokinetic model including demographic, clinical and laboratory covariates of patients was developed. RESULTS: The PKs of magnesium sulfate was well characterized by a one-compartment model. The population clearance 1.38 L/h, volume of distribution 13,3 L and the baseline magnesium concentration was 0,77 mmol/L (1,87 mg/dL). The covariates weight and serum creatinine statistically influence the clearance and volume of magnesium distribution values, respectively. The model was parameterized as clearance (CL) and volume of distribution (V). CONCLUSION: The pharmacokinetics of magnesium sulfate in pregnant women with PE are significantly affected by creatinine and maternal weight. Pregnant women with PE and higher body weight have a higher volume of distribution and, consequently, a lower elimination rate of magnesium sulfate. Pregnant women with PE and higher serum creatinine value show lower clearance and, therefore, lower magnesium sulfaate elimination rate.

MEMBROS DA BANCA:
Presidente - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interna - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo ao Programa - 2276354 - LEANDRO DE SANTIS FERREIRA