Banca de QUALIFICAÇÃO: ELEN DIANA DANTAS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ELEN DIANA DANTAS
DATA : 15/12/2017
HORA: 14:00
LOCAL: SALA 2 DO PPGCF
TÍTULO:

DEVELOPMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF SOLID DISPERSIONS OF CHRYSIN

PALAVRAS-CHAVES:

Chrysin, solid dispersions, polymers, polymer matrix, physicochemical characterization and development.

PÁGINAS: 56
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Chrysin (5,7-dihydroxyflavone) has an excellent pharmacological potential as an antihypertensive, antioxidant, antidiabetic and anti-neoplastic activity. However, exhibits poor aqueous solubility and presents problems of absorption. This work aimed to develop solid dispersions (SD) of CR with the following polymers: polyvinylpyrrolidone (PVP-K30), polyethylene glycol (PEG), soluplus (SOL), kollidon (KOL) and hydroxypropylmethylcellulose (HPMC). The SDs were prepared by kneading (KND) and solvent evaporation (EV) methods. Physicochemical characterization was performed by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry (TG), X-Ray Diffraction (XRD) and Scanning Eletronic Microscopy (SEM). All of these approaches indicated that the SDs were able to induce changes in the physicochemical properties of CR, which suggests interaction of polymer with CR. Among the results stands out a significant decrease of the crystalline reflections in the XRD and the displacement or suppression of the melting temperature of CR in the DSC, suggesting that the PLMs were able to incorporate the CR in its polymer matrix.

MEMBROS DA BANCA:
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Interno - 1679481 - ANA PAULA BARRETO GOMES
Interno - 6330567 - TULIO FLAVIO ACCIOLY DE LIMA E MOURA