Banca de QUALIFICAÇÃO: MARIA APARECIDA DE ARAUJO PEREIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARIA APARECIDA DE ARAUJO PEREIRA
DATA : 26/06/2017
HORA: 14:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

NANOPARTÍCULAS LIPÍDICAS SÓLIDAS DE 1,3-DIESTEARIL-2-
OLEIL-GLICEROL FUNCIONALIZADAS COM CARGA POSITIVA
PARA LIBERAÇÃO MODIFICADA DE PAPAÍNA

PALAVRAS-CHAVES:

Solid Lipid Nanoparticle; Papain; TG1; Healing.

PÁGINAS: 86
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Solid lipid nanoparticles (SLN) are applied colloidal systems as carriers of drugs
and biomolecules acting to increase stability and the ability to cross biological
barriers. In the present study, the triglyceride 1,3-distearyl-2-oleyl-glycerol (TG1)
was chosen as the lipid matrix of the particles due to its proven healing activity.
Papain is a complex combination of proteolytic enzymes and peroxidases,
extracted from the latex of papaya Carica papaya with potential healing action.
The aim of the present study was to develop and characterize SLN from cationic
TG1 (SLNTG1) for modified release of papain with potential application in wound
healing. The particles were obtained by the emulsification method with solvent
evaporation and characterized by their size, polydispersity and zeta potential using
the Dynamic Light Scattering technique. Successful cationic SLNTG1 were
obtained with sizes below 300 nm, polydisperion in the 0.2 range and positive zeta
potential. Infrared analyzes (FTIR-ATR) proved the interactions between the
constituents in the samples. Elevated concentrations of BSA protein incorporation
were achieved, about 98%. Cell viability assays have shown increased uptake of
cationic SLNTG1 by cells and the biocompatibility of the systems.

MEMBROS DA BANCA:
Externo ao Programa - 3652554 - FRANCISCO CANINDE DE SOUSA JUNIOR
Presidente - 1490222 - SILVANA MARIA ZUCOLOTTO LANGASSNER