Banca de DEFESA: JÉSSICA CAVALCANTE DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JÉSSICA CAVALCANTE DOS SANTOS
DATA : 27/03/2017
HORA: 09:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

A RELAÇÃO DE VCAM-1, ICAM-1, E-SELECTINA E MMP9 CIRCULANTES COM A EXTENSÃO DA LESÃO CORONÁRIA

PALAVRAS-CHAVES:

VCAM-1; ICAM-1; E-selectin; MMP9; Atherosclerosis

PÁGINAS: 74
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Atherosclerosis is a chronic inflammatory process that affect the artery walls and it is considered the primary origin of cardiovascular disease. Since there is a lack of complementary techniques to improve the early diagnosis of this disease, this work aimed to evaluate the relationships between inflammatory molecules and the presence and extension of the lesion. Participated in the study 74 patients who were undergoing coronary angiography for the first time and to assess the extent of the coronary lesions we used the Friesinger Index. The serum concentrations of the intercellular adhesion molecule-1 (ICAM-1), vasocellular adhesion molecule-1 (VCAM-1), E-selectin and matrix metalloproteinase-9 (MMP9) were measured using a multiplex immunoassay using the Luminex technology. Biochemical measurements - glucose, total cholesterol and fractions, creatinine K, uric acid, alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) - were performed by means of colorimetric and enzymatic methods. Clinical and biochemical data were correlated using the SPSS software. The VCAM-1 concentration higher than 86 ng/mL was noted in subjects with intermediate and major lesions (p <0.001 and p = 0.020, respectively). In addition, a logistic regression analysis showed that these patients had an increased risk of having an intermediate lesion (odds ratio (OR): 9.818; 95% confidence interval (CI): 1.840-52.384; p = 0.007). Interestingly, all patients with major lesions had concentrations of VCAM-1 higher than 86 ng/mL. No association was found between the degree of injury and the other proteins investigated, although ICAM-1 was strongly associated with this molecule (p = 0.02; r2=0.29). Therefore, a VCAM-1 molecule is strongly associated with a prediction of cardiovascular disease and degree of atherosclerosis.

MEMBROS DA BANCA:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Interno - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo à Instituição - THALES ALLYRIO ARAUJO DE MEDEIROS FERNANDES - UERN