Banca de QUALIFICAÇÃO: WALTER FERREIRA DA SILVA JUNIOR

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : WALTER FERREIRA DA SILVA JUNIOR
DATA : 28/11/2016
HORA: 14:00
LOCAL: SALA DE AULA I PPGCF
TÍTULO:

Development  and  physicochemical  characterization  of  solid 
dispersions  of  triterpenic  mixture  α, β amyrin 

PALAVRAS-CHAVES:

α, β amyrin, pentacyclic triterpenes, solid dispersions, hydrophilic 58 polymers, physicochemical characterization.

PÁGINAS: 67
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

α, β amyrin is a natural mixture of pentacyclic triterpenes and has a large biological activity, such as anti-inflamatory, and are isolated from the Burseraceae family species, in which Protium heptaphyllum specie is the most commonly found in the Brazilian Amazon. The present work aimed the development of solid dispersions (SD) of natural mixture α, β amyrin, which presents anti-inflammatory activity, with polyvinylpyrrolidone (PVP-K30), polyethyleneglycol (PEG-6000) and hydroxypropylmethylcellulose (HPMC) by kneading (KND) and rotaryevaporator (RE) methods. Physicochemical characterization was realized to verify if occurred interaction between ABAM and hydrophilic polymers, through of Fourier transform infrared, scanning electronic microscopy, powder X-ray diffraction, thermogravimetry and differential scanning calorimetry. Physicochemical characterization results indicate the SD are capable of promoting change in the physicochemical characteristics of ABAM, that was confirmed changes in the crystallinity of the sample by the technique of XRD and DSC and the SEM showed the change of morphology due to the reduction of crystallinity. TG techniques showed greater thermal protection than ABAM conferred by polymers and FTIR indicated the formation of molecular dispersion. In conclusion, the present show the potentiality of SD as an efficient tool for improve stability and promote changes in physicochemical properties of the ABAM.

MEMBROS DA BANCA:
Externo à Instituição - BOLIVAR PONCIANO GOULART DE LIMA DAMASCENO - UEPB
Presidente - 1871916 - RAQUEL BRANDT GIORDANI
Interno - 6330567 - TULIO FLAVIO ACCIOLY DE LIMA E MOURA