Banca de DEFESA: JAIRO SOTERO NOGUEIRA DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JAIRO SOTERO NOGUEIRA DE SOUZA
DATA : 28/11/2016
HORA: 14:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

ESTUDO  DAS  INTERAÇÕES  DO  PRAZIQUANTEL  COM  CICLODEXTRINAS  EM  SISTEMAS  MULTICOMPONENTES 

PALAVRAS-CHAVES:

multicomponents cyclodextrins complex; praziquantel; molecular modeling; triethanolamine; N-methyl-pyrrolidone.

PÁGINAS: 81
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The use of cyclodextrin (CD) to enhace the praziquantel (PZQ) water solubility has been widely studied in the literature. In this present paper, the interaction has not yet studied between the PZQ and both the beta-cyclodextrin (β-CD) and hydroxyl-propyl-cyclodextrin (HP-β-CD) or its association with the solvents triethanolamine (TEA) and N-methyl-pyrrolidone (NMP) was carefully conducted with the purpose to enhance the water solubility of the PZQ. The solubility diagrams and job’s plot diagrams showed that water soluble complexes were formed with 1:1 stoichiometry. The association of the complexes with the TEA and NMP diminished considerably the complex stability and its solubility. However, throught the molecular modeling study it was showed that this effect may be beneficial for the output of the drug from the CD cavity, and consequently to benefit the drug absorption. The results showed up adequately enlightening to propose that these systems can be investigated to enhance the PZQ bioavailability.

MEMBROS DA BANCA:
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Interno - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externo ao Programa - 1803692 - FABRICIO GAVA MENEZES
Externo à Instituição - JOSÉ OTÁVIO CARRÉRA SILVA JÚNIOR - UFPA