Banca de QUALIFICAÇÃO: FLÁVIA EVELYN MEDEIROS FERNANDES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : FLÁVIA EVELYN MEDEIROS FERNANDES
DATA : 28/11/2016
HORA: 09:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

USO DE MEDICAMENTOS E PROLONGAMENTO DO INTERVALO QTc EM UMA UNIDADE DE TERAPIA INTENSIVA ADULTO

PALAVRAS-CHAVES:

Long QT syndrome; Intensive Care Units; Side Effects and Adverse Reactions Related to Medicines.

PÁGINAS: 82
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Objective: The objective of this study was to investigate the prevalence of QTc prolongation in critically ill patients, their risk factors and degree of association with the medications administered. Method: An observational, prospective, cross sectional conducted in a Intensive Care Unit (ICU) general, who conducted the analysis of QT interval by electrocardiogram (ECG) at admission to the unit and the research of drugs previously used for admission. Results: The prevalence of 33.9% was detected, and 13.3% had QTc> 500 ms. The age (OR 1.017, p = 0.00), temperature (OR 0.812, p = 0.01), diabetes (OR 1.440, p = 0.04), elective surgery (OR 1.852, p = 0.00), potassium (OR 0.828, p = 0.05) and magnesium (OR 1.514, p = 0.02) were shown to be risk factors for QTc prolongation. The amiodarone medication (OR 2.434, p = 0.02) and haloperidol (OR 3.333, p = 0.02) were associated with increased risk of QTc prolongation. The drugs cefazolin, cefepime, midazolam, nitroglycerin, norepinephrine, sufentanil and protamine were identified as new QTc prolongation inducers. In 69.9% of patients with long QT prescription drugs were also increased risk, being furosemide, ondansetron, pantoprazole metoclopramide and amiodarone the most frequently used. Conclusions: There was a significant prevalence of QTc prolongation in critical patients, who often receive drugs already related to QTc prolongation during their stay in the unit. Hypermagnesemia and exposure to a surgical procedure were identified as new risk factors for the occurrence of QTc prolongation. Other drugs not further described by AZCERT were identified as potential inducers QTc prolongation.

MEMBROS DA BANCA:
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externo ao Programa - 347795 - IVONETE BATISTA DE ARAUJO
Externo ao Programa - 2495713 - ROSIANE VIANA ZUZA DINIZ