Banca de QUALIFICAÇÃO: AMANDA KATARINNY GOES GONZAGA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : AMANDA KATARINNY GOES GONZAGA
DATA : 03/12/2018
HORA: 09:00
LOCAL: PROGRAMA DE PÓS-GRADUAÇÃO EM PATOLOGIA ORAL
TÍTULO:

OXIDATIVE STRESS AND EPIGENETICS ALTERATIONS: MECHANISMS INVOLVED IN THE PATHOGENESIS OF LICHEN PLANUS

PALAVRAS-CHAVES:

Lichen Planus; DNA Repair; Oxidative Stress; Acetylation; Immunohistochemistry.

PÁGINAS: 63
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO:

Lichen planus (LP) is a mucocutaneous, inflammatory and chronic disease, immunologically mediated by T lymphocytes (TL), mainly CD8+, which are cytotoxic to keratinocytes of the epithelial basal layer. Subepithelial infiltration of T lymphocytes contributes to the local production of cytokines that, in turn, stimulate the production of reactive oxygen species (ROS). The imbalance between the formation and removal of ROS generates a state known as oxidative stress, responsible for causing oxidative lesions in macromolecules and cellular structures, impairing their normal functions or resulting in cell death. In recent years, there has been a growing interest in the role of oxidative stress and its antioxidant defense mechanisms in the pathogenesis of inflammatory, autoimmune diseases and carcinogenic processes. Since DNA is particularly vulnerable to the oxidative attack, in addition to enzymatic and non-enzymatic antioxidant systems present in body fluids, cells have developed the ability to induce multiple DNA repair mechanisms, including base excision repair (BER). Recent evidence indicates that changes in DNA repair genes and proteins of the BER pathway (XRCC1 and APE1) may determine individual susceptibility to various types of malignancies and inflammatory and autoimmune diseases. Beyond genetic modifications, the influence of epigenetic events on the pathogenesis of various diseases has been well investigated. One of the most currently studied epigenetic mechanisms, is the histone acetylation, which seems to influence several cellular processes such as cell cycle progression, DNA repair and apoptosis. However, the way histone acetylation modulates the behavior of immunologically mediated lesions requires further investigation. In view of what has been exposed, the objective of this study is to first evaluate salivary indices of oxidative stress in patients with oral lichen planus (OLP) and the expression of proteins involved in DNA repair (XRCC1, APE1) in OLP and cutaneous lichen planus (CLP), as well as the histone H3K9 acetylation profile in these lesions, in order to identify mechanisms involved in its pathogenesis and, thus, understand possible factors associated with its different clinical subtypes and response to treatment.

MEMBROS DA BANCA:
Interno - 347125 - ANA MIRYAM COSTA DE MEDEIROS
Externo ao Programa - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interno - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL