Banca de DEFESA: ANDRÉIA FERREIRA DO CARMO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ANDRÉIA FERREIRA DO CARMO
DATA : 15/12/2017
HORA: 14:00
LOCAL: AUDITÓRIO DO DEPARTAMENTO DE ODONTOLOGIAUFRN
TÍTULO:

STANNIOCALCINA 2 MODULATES IMPORTANT ROLES IN ORAL TUMORIGENESIS AND IS STC2 IS A PROGNOSTIC MARKER FOR ORAL SQUAMOUS CELL CARCINOMA

PALAVRAS-CHAVES:

Carcinoma, Squamous Cell. Mouth Neoplasm. Cancer-Associated Fibroblasts. Biomarkers, Tumor. Prognosis.

PÁGINAS: 65
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO:

The glycoprotein hormone stanniocalcin 2 (STC2) is involved in carcinogenesis and progression of several cancer types. However, its clinical significance and molecular mechanisms in oral squamous cell carcinoma (OSCC) have been little studied and remain uncertain. In the present study, we investigated associations of STC2 expression with clinicopathological and survival parameters of OSCCs patients. We also determined the biological effects caused by STC2 downregulation in OSCC and cancer associated fibroblasts (CAF) cell lines. Immunohistochemical analysis in 100 cases of primary OSCC indicated that STC2 overexpression was correlated with N stage (TNM staging) and was an independent risk factor for disease-specific survival and disease-free survival  in patients with OSCC. Using in vitro assays, we demonstrated that STC2 knockdown in OSCC cell lines promoted apoptosis, and reduced cell proliferation, migration, invasion and epithelial-mesenchymal transition. Further analysis revealed that CAF expresses higher levels of STC2 than OSCC cells. Knockdown of STC2 in CAF reduced OSCC cell invasion, suggesting that STC2 released by CAF contributes to a more invasive phenotype in OSCC. These results suggest that STC2 modulates important events for oral tumorigenesis and can be a prognostic biomarker for OSCC patients.

MEMBROS DA BANCA:
Presidente - 350485 - HEBEL CAVALCANTI GALVAO
Interno - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL
Interno - 350484 - ROSEANA DE ALMEIDA FREITAS
Externo à Instituição - MANUEL ANTONIO GORDON NUNEZ - UEPB
Externo à Instituição - RICARDO DELLA COLLETA - UNICAMP