Banca de QUALIFICAÇÃO: JULIANA CAMPOS PINHEIRO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : JULIANA CAMPOS PINHEIRO
DATA : 30/10/2017
HORA: 08:30
LOCAL: AUDITÓRIO DO DEPARTAMENTO DE ODONTOLOGIAUFRN
TÍTULO:

Relationship between mast cells and E-cadherin in odontogenic keratocysts and radicular cysts.

PALAVRAS-CHAVES:

Odontogenic keratocyst, Radicular cyst, Mast cells, E-cadherin.

PÁGINAS: 62
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO:

Mast cells are multifunctional secretory cells of the immune system that participate in the regulation of the immune response by the release of chemical mediators. It can respond to different stimuli, and thus participate in a wide variety of physiological and pathological processes. Being responsible for the synthesis and release of numerous pharmacologically active products. Mast cell mediators include histamine, chymase, tryptase and TNF-α. Tryptase is a serine protease stored mainly by the mast cell granules found in most tissues. It is known that in the epithelial components there is a strong intercellular adhesion, being this tissue characteristic maintained by the junctional complex. The junctional complex consists of specialized membrane structures that regulate cell-cell adhesion, being essential for morphology and epithelial function. There are different types of cell-cell binding, with cadherin-mediated adhesions being further studied. E-cadherin is an element of the cadherin family known to play an important role in the regulation of intercellular adhesion in epithelial tissues. It is considered the main component in the junction of transmembrane adhesion of epithelial cells of all organs. The maintenance of the architecture of adult tissue depends greatly on the functional and structural integrity of cadherins. Cysts of the maxillo-mandibular complex can be classified into two groups according to their origin: odontogenic and non-odontogenic cysts. In turn, odontogenic cysts are subdivided into developmental and inflammatory cysts. Odontogenic keratocyst is considered a developmental cyst and usually presents as a solitary lesion exhibiting aggressive behavior, with a high potential for bone destruction. The radicular cyst is classified as an inflammatory odontogenic cyst. Tests of pulp vitality by cold, heat, and electricity are negative, that is, they reveal pulpal necrosis. Taking into account the multifunctionality of mast cells and based on the fact that these cell types may be related to the process of epithelial permeability whose relationship is still not very well established, the objective of the present study is to verify the possible relation between mast cells and the expression of E-Caderin with changes in intercellular junctions and consequent increase in epithelial permeability in odontogenic keratocysts and radicular cysts.

MEMBROS DA BANCA:
Interno - 350485 - HEBEL CAVALCANTI GALVAO
Interno - 346077 - LELIA BATISTA DE SOUZA
Presidente - 2859541 - PEDRO PAULO DE ANDRADE SANTOS