Banca de QUALIFICAÇÃO: LAUDENICE DE LUCENA PEREIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : LAUDENICE DE LUCENA PEREIRA
DATA : 01/09/2017
HORA: 08:30
LOCAL: SALA I DO DEPARTAMENTO DE ODONTOLOGIA
TÍTULO:

Analysis of the Thermal Shock Factor 1 (pHSF) in oral squamous cell carcinomas in tongue

PALAVRAS-CHAVES:

Oral squamous cell carcinoma, phosphorylated thermal shock factor 1, clinical-pathological aspects, immunohistochemistry, prognosis.

PÁGINAS: 64
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
RESUMO:

Oral squamous cell carcinoma (CCEO) is the most common cancer in the world, accounting for 95% of all neoplasms affecting the oral cavity presenting high rates of morbidity and mortality in the population. Therefore, the scientific community makes efforts to detect morphological alterations or to identify biomarkers that can categorize the prognosis of patients, follow the progression of the disease with predictive power of relapse and metastasis, and seek new strategies and / or individualized therapeutic options. It is known that the thermal shock factor 1 (HSF1) allows the cells to deal with stressful situations associated with malignancy, acting in different ways in the tumor progression. The phosphorylated form of this factor has a function still poorly understood, but it is known that it is involved in its activation. This research aims to analyze whether the phosphorylated form of the heat shock factor 1 exerts some influence on the CCEO pathogenesis and survival of the patients, in order to better understand the role of this molecule in carcinogenesis of these tumors. To do so, a histomorphological study will be performed through the gradation of malignancy by Bryne et al. (1998), Brandein-Gensler (2005) and BD model (Almangush et al, 2014) in 50 cases of oral squamous cell carcinoma of tongue (CCELO). Then, the 50 specimens and 20 cases of normal oral mucosa as a control will be submitted to an immunohistochemical study to evaluate the expression of the phosphorylated form of the HSF1 protein (pHSF1) then the association of this immunoexpression will be sought with some pathological parameters, such as Histological grading of malignancy and clinical correlation with patient survival

MEMBROS DA BANCA:
Interno - 1258707 - ANTONIO DE LISBOA LOPES COSTA
Interno - 1258693 - LELIA MARIA GUEDES QUEIROZ
Interno - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL