Banca de QUALIFICAÇÃO: MARIA LUIZA DINIZ DE SOUSA LOPES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : MARIA LUIZA DINIZ DE SOUSA LOPES
DATA : 25/08/2017
HORA: 09:00
LOCAL: SALA DA PÓS-GRADUAÇÃO EM PATOLOGIA ORAL
TÍTULO:

 IMMUNE RESPONSE AND EVASION MECHANISMS IN LIP CARCINOGENESIS: AN IMMUNOHISTOCHEMICAL STUDY

PALAVRAS-CHAVES:

Squamous cell carcinoma; Cheilitis; Lip neoplasms; Immune Evasion; Cytotoxicity, Immunologic; Immunohistochemistry

PÁGINAS: 67
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
RESUMO:

Chronic exposure to solar ultraviolet (UV) radiation can cause serious consequences, including irreversible cell damage related to the development of squamous cell carcinoma (SCC) of the lip, and precursors disorders such as actinic cheilitis (AC). It is well established that human immune system has the ability to recognize and destroy altered cells in a process known as immune surveillance, often mediated by CD8+ T lymphocytes, which secret cytotoxic granules like granzyme B, to induce apoptosis on the target cell. However, some mutated keratinocytes can evade the immune surveillance through inhibitory signals, besides the UV radiation itself exert an immunosuppressive effect. One of these inhibitory signals is mediated by programmed death receptor (PD-1) mainly expressed in activated lymphocytes, which causes apoptosis of these cells once it interacts with it ligand PD-L1 located on the surface of tumor cells and inflammatory cells. Other inhibitory protein is the non-classical human leucocyte antigen-G (HLA-G), that exhibits immunoregulatory functions such as suppression of T lymphocytes cytotoxic activity. PD-L1 and HLA-G overexpression has been observed in human malignant tumors of many anatomical locations, when compared to normal tissues or potentially malignant disorders. Additionally, an elevated expression of these molecules has been associated to more aggressive tumors, and to worse prognosis for the patients. In this context, there is a great interest in the immunotherapeutic potential offered by the blockage of these inhibitory molecules. Based on the above considerations, the objective of this study is to investigate and compare the immunoexpression of PD-L1, HLA-G, CD8 and GB in the microenvironment of SCCs of the lip, ACs and normal lip mucosa. The results of the study may help in better elucidating the participation and relationship between these molecules in the malignant transformation and progression of lip cancer.

MEMBROS DA BANCA:
Presidente - 2492713 - ERICKA JANINE DANTAS DA SILVEIRA
Interno - 346077 - LELIA BATISTA DE SOUZA
Interno - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL