Banca de DEFESA: VILSON LACERDA BRASILEIRO JUNIOR

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : VILSON LACERDA BRASILEIRO JUNIOR
DATA : 23/02/2017
HORA: 08:30
LOCAL: PROGRAMA DE PÓS-GRADUAÇÃO EM PATOLOGIA ORAL
TÍTULO:

ANALYSIS OF IMMUNOISTOKYMIC EXPRESSION OF REGEN AND PROTEINS INVOLVED IN REGULATION OF APOPTOSIS IN EPIDERMAL CARCINOMAS OF ORAL LANGUAGE.

PALAVRAS-CHAVES:

Oral squamous cell carcinoma, Oral tongue squamous cell carcinoma, Apoptosis, Proteasome activators, p53 tumor suppressor protein.

PÁGINAS: 108
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO:

Cancer of the oral cavity is one of the most common malignancies in the world. Since the development of malignant neoplasms is related to damage that causes an imbalance in the regulation of cell division and cell death, many studies have been conducted in recent years to verify the influence of this damage on overall cell behavior and on the progression of the disease. Within this context, recent studies suggest that changes in the expression of REGg play an important role in the progression of different malignant tumors by interfering with the regulation of apoptosis. Therefore, the objective of the present study was to investigate the immunohistochemical expression of REGg, p53, MDM-2, Bcl-2 and Bax in oral tongue squamous cell carcinoma (OTSCC), correlating the immunoexpression of these proteins with clinical-pathological parameters of tumor aggressiveness, in order to determine whether REGg contributes to tumor progression and interferes with the expression of apoptosis-related proteins. For this purpose, the clinical data of 58 patients with OTSCC were collected and paraffin-embedded tumor specimens were submitted to histopathological analysis and immunohistochemistry using the markers cited above. The results showed significantly higher expression of REGg (p<0.05) in low-grade tumors and without lymph node metastases. In addition, comparison of the expression patterns of p53, MDM-2 and Bax according to the clinical-pathological parameters studied revealed no significant differences in the percentage immunostaining for these markers. Regarding Bcl-2, significantly lower percentage immunostaining for this protein was observed in tumors with a high grade of malignancy and tumors associated with deaths related to the disease (p<0.05). Finally, Spearman’s correlation test demonstrated a significant weak positive correlation between the percentages of REGγ and of MDM-2 and Bcl-2. These findings suggest that the increase in the expression of REGg does not contribute to the progression of OTSCC, but may influence the expression of proteins related to the regulation of apoptosis.

MEMBROS DA BANCA:
Externo à Instituição - CASSIANO FRANCISCO WEEGE NONAKA - UEPB
Presidente - 346077 - LELIA BATISTA DE SOUZA
Interno - 1258693 - LELIA MARIA GUEDES QUEIROZ
Externo à Instituição - MARCIO CAMPOS OLIVEIRA - UEFS
Interno - 350484 - ROSEANA DE ALMEIDA FREITAS