CHRONONUTRITIONAL BEHAVIORS, SLEEP/WAKE PATTERNS AND GLYCEMIC CONTROL IN PEOPLE WITH TYPE 2 DIABETES MELLITUS
metabolic diseases, chrononutrition, chronotype, gastrointestinal health, physical activity.
INTRODUCTION: Type 2 diabetes mellitus (T2DM) constitutes a significant public health challenge, particularly due to the chronic complications resulting from inadequate glycemic control. Evidence indicates that factors such as sleep/ patterns and chrononutritional behaviors can influence glycemic regulation in individuals with T2DM. However, understanding the interactions between these and other factors in glycemic control remains limited, especially in the Brazilian context. OBJECTIVE: To evaluate the association between chrononutritional behaviors, sleep patterns, living conditions, and health parameters with glycemic control in adults and elderly individuals with T2DM in the municipality of Santa Cruz, RN, Brazil. MATERIALS AND METHODS: This is a quantitative, cross-sectional, and observational study conducted with adults and elderly individuals with T2DM in Santa Cruz, RN. Data collection took place between April and July 2024. Participants who met the inclusion criteria and signed the informed consent form were subjected to an anthropometric assessment (weight, height, and waist circumference) and completed five questionnaires: (1) Socioeconomic and Health Parameters Questionnaire; (2) International Physical Activity Questionnaire (short version); (3) Gastrointestinal Health Questionnaire; (4) Chrononutritional Profile Questionnaire; (5) Munich Chronotype Questionnaire. Glycemic control was assessed using glycated hemoglobin (HbA1c) testing at a partner laboratory, utilizing quantitative values and classification according to the therapeutic targets recommended by the Brazilian Diabetes Society. The normality of the variables was verified using the Kolmogorov-Smirnov test. The Student’s T-test was applied to compare the means of parametric quantitative variables between groups with adequate and inadequate glycemic control. For variables with non-normal distribution, the Mann-Whitney test was used, which was also employed to compare the mean HbA1c values across dichotomized categorical variables. A 5% level of statistical significance was adopted for all tests. PRELIMINARY RESULTS: A total of 86 individuals were evaluated, of whom 79.1% were women and 53.5% were adults. Significant differences in mean ranks of HbA1c were identified in relation to sex (p=0.029), insulin use (p=0.001), presence of neuropathy (p=0.038), and nighttime eating behavior (p=0.035). Additionally, associations were found between glycemic control and age (p=0.04) and gastrointestinal symptoms (p=0.024). CONCLUSIONS: Knowledge about chrononutritional behaviors associated with glycemic control is essential for the development of clinical strategies and public policies aimed at improving quality of life and preventing complications in individuals with T2DM.