CORRELATES OF BIOPSYCHOSOCIAL VARIABLES IN THE PAIN SCENARIO CHRONICLE: FATIGUE AND CHRONOBIOLOGICAL PARAMETERS IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
Systemic Lupus Erythematosus. Ache. Fatigue. Chronobiology. Actimetry.
Systemic Lupus Erythematosus (SLE) is known to have an impact on the health of individuals and is supported by a network of multiple factors that culminates in its various chronic consequences, such as symptoms of pain, fatigue, changes in sleep patterns and changes in humor. OBJECTIVE: to reflect on the interrelationships between sleep, fatigue and pain parameters in patients with SLE, as well as to search for new markers that can influence their behaviors, such as mood, rest-activity rhythm and exposure to light . METHODOLOGY: The research design is characterized as a cross-sectional observational study with the residences of patients (for physically limited patients) and the Laboratory of Neurobiology and Biological Rhythmicity (LNRB) of UFRN as their collection point, where 8 validated questionnaires were applied, divided into 2 stages interspersed by the use of the Actimeter in 2 groups of women, with and without the diagnosis of SLE. Descriptive statistical analyzes of the obtained variables were carried out, including the determination of the characteristic of the distribution of each variable and later the inferential statistical analysis in order to seek the differences between the groups and the relationships between the variables mentioned above. RESULTS: 46 variables were analyzed in order to clarify the scenario experienced by patients with Systemic Lupus Erythematosus. Differences between groups were found for variables of pain, fatigue, quality of sleep, social jetlag, depression, variables of exposure to light and relative amplitude of the activity-rest rhythm. In the lupus group, an association was found between fatigue and pain, as well as between pain and sleep, but the same did not happen for fatigue and sound, with fatigue being justified by perceived stress. Only subjective sleep variables were associated with the activity level of the disease and over-spending was predictive of sleep efficiency. Variables in the rhythm of activity and rest were associated with sleep variables, but only L5 was a predictive variable for sleep duration. Anxiety was able to predict disease activity and this in turn was responsible for the behavior of subjective pain variables. CONCLUSION: The findings demonstrate that it is important to consider chronobiological variables, from exposure to light, activity-rest rhythm and sleep-wake cycle, in the treatment of patients with Systemic Lupus Erythematosus and that mood control contributes to the modulation of disease activity .