Banca de DEFESA: ARTHUR FERNANDO SILVA ANDRADE DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR FERNANDO SILVA ANDRADE DOS SANTOS
DATE: 30/06/2026
TIME: 15:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

DEVELOPMENT OF LOW-ENERGY NANOEMULSION SYSTEMS CONTAINING PRAZIQUANTEL FOR THE POTENTIAL TREATMENT OF PLATYNOSOMIASIS

KEY WORDS:

platinosomiasis; nanoemulsions; praziquantel; bioavailability.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Platinossomiasis is a parasitic infection caused by trematodes of the genus Platynossomum, which primarily affects domestic cats. The parasite has a complex life cycle involving multiple hosts, and the pathophysiology of the infection may cause severe hepatic damage, requiring effective therapeutic approaches. Praziquantel is the first-line active pharmaceutical ingredient (API) for the treatment of platinossomiasis; however, its bioavailability is limited due to its low water solubility and first-pass metabolism, which create significant clinical challenges. Therefore, the use of nanoemulsions, colloidal systems composed of nanometric droplets, represents a promising strategy to improve drug absorption and efficacy. Nanoemulsions were developed using the phase inversion technique, and their droplet size, zeta potential, pH, morphology, and stability were evaluated by dynamic light scattering, electrophoretic mobility, and transmission electron microscopy (TEM). The developed formulations showed significant variations over 56 days, with notable statistical differences in droplet diameter. The most stable nanoemulsions showed size variations from 188.7 to 193.8 nm (+5.1 nm), from 216.9 to 185.5 nm (-31.4 nm), and from 193.8 to 272.9 nm (+79.1 nm), respectively. After praziquantel incorporation, the mean particle diameter between the first and last day changed from 181.0 to 283.2 nm (+102.2 nm) and from 125.3 to 152.6 nm (+27.3 nm). The presence of praziquantel also revealed instability phenomena that negatively affected formulation performance. These findings suggest that optimizing PZQ concentrations is crucial not only to maximize system stability, but also to improve therapeutic efficacy. The presented nanoemulsions demonstrate good potential for the treatment of platinossomiasis.

COMMITTEE MEMBERS:
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Externo à Instituição - DOUGLAS DOURADO OLIVEIRA - Fiocruz - PE
Externo ao Programa - 2941160 - JOSE HERIBERTO OLIVEIRA DO NASCIMENTO - nullInterno - 2275890 - MARCELO DE SOUSA DA SILVA