Low-Energy Development of Andiroba and Copaiba Oil Nanoemulsion for Potential Wound Healing Applications
Antimicrobial, nanotechnology, andiroba oil, copaiba oleoresin, nanoemulsion.
The skin is the largest organ of the human body and serves as the first line of defense
against external agents. When its integrity is compromised, susceptibility to microbial
infections increases. This, combined with the rapid development of microorganisms
resistant to conventional antimicrobials, can lead to a severe disruption of the body's
homeostasis. Andiroba (Carapa guianensis) is a tree native to the Amazon region and
was already used for various therapeutic purposes by the indigenous peoples before
the discovery of the American continent. Some studies have conducted in vitro
research and observed its antimicrobial effects. To enhance this effect, the use of
nanotechnology was considered, combining the fixed oil of this plant with the oleoresin
of Copaiba (Copaifera officinalis). Thus, the objective of this study was the
development and characterization of a nanoemulsion formulation encapsulated with
filtered fixed andiroba oil and copaiba oleoresin, using the low-shear phase inversion
technique. The prepared formulations were characterized by particle size analysis,
Polydispersity Index, Zeta Potential, Hydrogen Potential (pH), Antioxidant Activity,
Antibacterial and Antifungal Activity. So far, it has been possible to develop stable
products with potential therapeutic activity for the treatment of infections.