Banca de DEFESA: CINTIA GABRIELA DE SOUZA LACERDA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CINTIA GABRIELA DE SOUZA LACERDA
DATE: 10/06/2025
TIME: 09:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

Anti-inflammatory and antioxidant activity of Varronia curassavica’s extracts

in preclinical studies: a systematic review

KEY WORDS:

Cordia verbenacea; extract; inflammation.

PAGES: 88
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Varronia curassavica Jacq. is a native and non-endemic species of Brazil, and plant derivatives

obtained from the species are popularly used for the treatment of inflammatory diseases in

general. In Brazil, there is a phytotherapeutic medicine registered with ANVISA that has the

essential oil of the species as an active ingredient. It is known that extracts and essential oils

are plant derivatives; however, they have different chemical compositions. Within this context,

the anti-inflammatory pharmacological effect of the essential oil obtained from the leaves

cannot be extrapolated to other plant derivatives obtained, for example, with water and ethanol.

Therefore, it is justified to conduct a systematic review with the species to assess whether there

is preclinical evidence that proves the efficacy, safety, and quality of plant derivatives obtained

with organic solvents and water. Therefore, the objective of this study was to evaluate the

antioxidant and anti-inflammatory capacity of Varronia curassavica (erva-baleeira) in

preclinical models through a systematic review of the literature. To conduct this systematic

review, the checklist contained in the Preferred Reporting Framework for Systematic Reviews

and Meta-Analyses (PRISMA) was used as a guide for study selection, screening and eligibility.

The guiding question of this review is “What is the antioxidant and anti-inflammatory capacity

of Varronia curassavica (erva-baleeira) using preclinical models?”. MeSH and non-MeSH

terms were used for the search strategy and the search was conducted in PubMed-Medline,

Scopus, Web of Science and Embase. With the selected studies, data extraction and risk of bias

assessment were performed using the Systematic Review Center for Laboratory Animal

Experimentation (SYRCLE) risk of bias tool. As a result, it was possible to highlight in this

systematic review that the leaves were the part of the plant most used by the studies, being

subjected to maceration c in most cases, with ethanol or 70% ethanol. Six studies conducted

with extracts identified four main substances: rosmarinic acid, artemetin, briquelin, and

cordialin A. The results observed in preclinical studies with animals showed that, administered

orally, the extract was able to decrease the expression of pro-inflammatory cytokines, such as

TNF-α, IL-6, and IL-1β, edema, and increase important antioxidant enzymes, such as catalase

and GSH. In contrast, the essential oil, administered orally, was also able to reduce edema and

TNF-α; however, it did not cause changes in IL-1β and PGE2. The methodological quality of

the studies included in this systematic review was predominantly classified as low risk, since

most of the criteria necessary to assess bias in the study were sufficiently reported. In

conclusion, the results suggest that V. curassavica extracts have anti-inflammatory and

antioxidant potential in preclinical in vivo models. It was observed that the ethanolic and

hydroethanolic extracts obtained by maceration from the leaves of erva-baleeira were capable

of combating inflammation in preclinical models in vivo, using the oral route of administration

as the main route.

COMMITTEE MEMBERS:
Externo à Instituição - ANDRÉ GONZAGA DOS SANTOS - UNESP
Interna - 1871916 - RAQUEL BRANDT GIORDANI
Presidente - 1490222 - SILVANA MARIA ZUCOLOTTO LANGASSNER