Banca de DEFESA: IAN ANTUNES FERREIRA BAHIA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : IAN ANTUNES FERREIRA BAHIA
DATE: 29/07/2024
TIME: 10:00
LOCAL: SALA 2 DO PPGCF
TITLE:
Immunophenotype signatures in acute leukemias unveiled by integrative systems immunology
 

KEY WORDS:
acute leukemias; integrative systems analysis; immunophenotyping.

PAGES: 61
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Acute leukemias (ALs) are complex hematological disorders, and accurate
diagnosis is crucial for guiding treatment decisions and predicting patient outcomes.
While changes in cell marker levels are well documented, the impact of these changes
on marker relationships through an integrative systems approach remains
uncharacterized. To address this gap, we conducted a 12-year study investigating 41
markers, including ontogenic markers and those used to diagnose both common and
rare leukemia types, using immunophenotyping flow cytometry (IFC) data from 1,069
leukocyte samples obtained from peripheral blood leukocytes (PBL) or bone marrow
(BM) aspirates of patients with suspected ALs. Machine learning techniques, such as
principal component analysis (PCA) and random forest (RF) classification,
demonstrated the stratification power of the cellular markers. Hierarchical clustering
analysis of leukocyte ontogenetic markers revealed disease-specific clusters,
irrespective of sex or sample type (PBL or BM). Additionally, we found that patients
with acute myeloid leukemia (AML) showed mild disruption in cell marker correlations,
whereas the most significant dysregulation was observed in patients with T-cell acute
lymphoblastic leukemia (T-ALL). Importantly, we identified ontogenic correlation
changes indicating clusters of immature versus mature leukocyte markers, as well as
cell lineage-specific markers influencing cellular relationships. These findings
underscore the value of integrating systems strategies into conventional IFC analyses
to enhance synthetic diagnosis and deepen our understanding of ALs pathophysiology.

COMMITTEE MEMBERS:
Externo à Instituição - ALDAIR DE SOUSA PAIVA - IAPC
Externo ao Programa - 2611909 - CARLOS RAMON DO NASCIMENTO BRITO - nullPresidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Notícia cadastrada em: 15/07/2024 15:24
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