Banca de DEFESA: JOSEFA VIVIANE DE MOURA FERREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JOSEFA VIVIANE DE MOURA FERREIRA
DATE: 31/03/2026
TIME: 14:00
LOCAL: Plataforma Google Meet
TITLE:

Audiological diagnosis in infants with congenital cytomegalovirus during the first six months of life

KEY WORDS:

Hearing; cytomegalovirus; auditory brainstem evoked potential; infants.

PAGES: 38
BIG AREA: Ciências da Saúde
AREA: Fonoaudiologia
SUMMARY:

Congenital cytomegalovirus (cCMV) is considered the main risk indicator for sensorineural
hearing loss among congenital infections. This dissertation comprises two studies. Article 1 aimed to
map and characterize the audiological procedures and their order of execution in the diagnosis of
infants up to 24 months of age. Article 2 investigated middle ear and cochlear function, the neurophysiological integrity of the auditory pathway up to the brainstem, and estimated auditory
thresholds through electrophysiological and behavioral measures in infants with cCMV. Method: In
Article 1, the search was conducted in the Medline database and in the Web of Science, LILACS,
SciELO, Embase, Scopus, CINAHL, Google Scholar, and ProQuest Dissertations and Theses (PQDT)
databases, using the following question: “Is there a consensus regarding the procedures performed in
the audiological diagnosis of infants from 0 to 24 months?”. Article 2 consisted of an observational
cross-sectional study approved by the Research Ethics Committee of the Onofre Lopes University
Hospital (No. 7,190,153). A total of 314 infants were recruited from two public maternity hospitals in
Natal. Participants were divided into two groups: G1 (cCMV, positive urine PCR up to 21 days of life)
and G2 (probable perinatal CMV, positive PCR after 21 days). All infants underwent transient evoked
otoacoustic emissions (TEOAE), tympanometry, Auditory Brainstem Response with click stimulus
(click-ABR), and frequency-specific ABR (FS-ABR), in addition to behavioral assessment (Ling
sounds, attention, sound localization, and cochleopalpebral reflex). Results: In the review, the searches
conducted on January 17, 2026 identified 6,983 articles, of which six were included in the final version. In Article 2, 12 infants (G1 = 6; G2 = 6), aged between 2 and 6 months, were evaluated. In
G1, two infants (33.3%) presented absent OAEs in at least one frequency band; one (16.7%) did not
undergo the examination; and three (50%) presented bilaterally present OAEs. One infant presented
tympanometry with a bilateral negative peak. In the click-ABR at 70 dB, waves I, III, and V were
observed with latencies and interpeak intervals within normal limits. In the frequency-specific ABR
(500, 2000, and 4000 Hz), four infants (66.7%) presented normal electrophysiological thresholds,
while two (33.3%) showed conductive alteration at 500 Hz (AC = 45 dB; BC = 20 dB nHL). In G2,
four infants (66.7%) presented absent OAEs in at least one frequency band, while two (33.3%)
presented bilaterally present OAEs. In the click-ABR, all infants presented waves I, III, and V with
latencies within normal limits, and in the frequency-specific ABR they presented normal thresholds at
all evaluated frequencies. Conclusion: The findings of the review indicate that the audiological
diagnosis in infants up to 24 months may follow the sequence: tympanometry, OAEs, click-ABR, and
frequency-specific ABR through air and bone conduction at frequencies of 500, 1000, 2000, and 4000
Hz. In Article 2, no infant with CMV was diagnosed with sensorineural hearing loss at the time of
evaluation. However, the frequent occurrence of absent OAEs in at least one frequency band in both
groups reinforces the need for continuous audiological monitoring, considering the risk of late or
progressive hearing alterations associated with CMV.

 

 

COMMITTEE MEMBERS:
Interna - ***.092.134-** - KELLY CRISTINA LIRA DE ANDRADE - UNCISAL
Externa à Instituição - MARIA ANGELINA NARDI DE SOUZA MARTINEZ - PUC - SP
Presidente - 1804274 - SHEILA ANDREOLI BALEN