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Dissertations |
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1
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RAMON CIPRIANO PACHECO DE ARAÚJO
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Effectiveness of a therapeutic program based on CTAR exercises compared to the chindown maneuver in dysphagic patients with Parkinson's disease
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Advisor : HIPOLITO VIRGILIO MAGALHAES JUNIOR
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COMMITTEE MEMBERS :
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HIPOLITO VIRGILIO MAGALHAES JUNIOR
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MARINA MARTINS PEREIRA PADOVANI
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LUCIA FIGUEIREDO MOURÃO
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Data: Jan 30, 2025
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Show Abstract
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Dysphagia is a condition frequently associated with Parkinson's disease (PD) and can cause not only a decline in quality of life, malnutrition, dehydration, and fear of eating but also increase the risk of aspiration pneumonia, the main cause of death in these patients. Although there is drug treatment for motor symptoms, increasing doses does not guarantee improvement in swallowing disorders. Interventions for oropharyngeal dysphagia include those based on the chin-down postural maneuver, which has shown positive effects on the efficiency and safety of swallowing in PD patients. However, other interventions are being developed, such as the Chin Tuck Against Resistance (CTAR) technique, a promising therapeutic proposal for rehabilitating swallowing function. However,h there is still no published data on its effectiveness in the Parkinson's population. Therefore, this study aims to investigate the efficacy of an intervention program based on CTAR exercises, compared to the chin-down postural maneuver, in dysphagic patients with PD. Ethical principles were complied with and the project was approved by the Research Ethics Committee. The first study was a randomized clinical trial. It included 26 individuals with PD who were randomly allocated to two intervention groups for 4 weeks. Group A performed the CTAR exercises and functional swallowing training, while Group B performed the chin-down maneuver with functional swallowing training with different food consistencies. The outcomes evaluated included clinical assessment of swallowing, maximum isometric tongue pressure, quality of life, and peak cough flow, measured before and after the intervention period. The CTAR group showed a significant improvement in clinical assessment of swallowing, maximum isometric tongue pressure, and quality of life compared to the chin-down group. However, there was no significant difference in peak cough flow between the two groups. The second study, longitudinal in nature, compared the maximum isometric progression of the tongue over the 4 weeks of intervention. The analysis between the groups revealed a significant difference in the increase in tongue pressure in the CTAR group compared to the chin-down group in all the weeks of intervention. The highest peak measurement occurred in the third week and the effect size was considered large. The exploratory studies suggest the efficacy of CTAR exercises in the rehabilitation of dysphagia in PD patients, highlighting them as a promising and efficient approach.
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2
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MARIA GABRIELA PAZ DA SILVA
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Age-Related Cochlear Synaptopathy in Rats: The Use of Short-Latency Auditory Evoked Potentials
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Advisor : ELIENE SILVA ARAUJO
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COMMITTEE MEMBERS :
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ELIENE SILVA ARAUJO
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KELLY CRISTINA LIRA DE ANDRADE
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KÁTIA DE FREITAS ALVARENGA
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Data: Mar 6, 2025
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Show Abstract
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Introduction: In the natural aging process, a decrease in synapses occurs between inner hair cells and spiral ganglion neurons of the auditory nerve, a phenomenon known as cochlear synaptopathy (CS). Studies suggest that short-latency auditory evoked potentials (AEP) can identify CS, but there are still gaps in the protocols and parameters used for this identification in clinical practice.Objective: To evaluate the applicability of short-latency AEPs in identifying aging-related CS in rodents. Method: Two studies were conducted. The first was a systematic literature review, registered in PROSPERO (CRD42025615318), aiming to synthesize data on the sensitivity of short-latency AEPs in identifying CS in aging rodents. The review followed the recommendations of the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA), with searches conducted in the PUBMED/MEDLINE, Cochrane Library, Scopus, Embase, Web of Science, Scielo, and LILACS databases, as well as gray literature. Article selection was performed independently and blindly by two reviewers, with the assistance of Rayyan and EndNote tools. The second study was a cross-sectional observational study, approved by the Animal Use Ethics Committee (protocol No. 2024-02-ISD). Ten healthy Wistar rats of both sexes, with no prior noise exposure, were used and divided into age groups: G1 (3–4 months), G2 (10 months), G3 (14–15 months), and G4 (24 months). The animals underwent auditory brainstem response (ABR) recording using the Eclipse equipment (EP25 model) under sedation. Electrodes were positioned at Fz (active), M1 and M2 (references), and the right paw (ground), with impedance below 5 kΩ. Click stimuli with alternating polarity at 90, 85, and 80 dBnHL were presented to each ear through 3A insert earphones at stimulation rates of 33.1, 15.1, and 7.1 clicks/s. The amplitudes of waves I and IV were analyzed blindly by two specialists. Data underwent descriptive and inferential statistical analysis in SPSS, adopting p<0.05. Results: In Study 1, 2,684 articles were identified, of which 15 were included. The most used model was the mouse (n=13), followed by Fisher 344 rats (n=1) and Wistar rats (n=1), with ages ranging from 3 to 33 months. All studies used ABR to identify CS, with wave I amplitude being the most frequent biomarker, and all confirmed CS through neurobiological analysis. In Study 2, examiner agreement was excellent (>90%). The mean amplitude was 1.33±0.69 μV for wave I and 0.75±0.62 μV for wave IV. Age did not influence the results, but a sex effect was observed. Wave I showed greater amplitude at 7.1 clicks/s compared to 33.1 clicks/s. Conclusion: Short-latency AEP demonstrated applicability in identifying CS in rodents, with wave I amplitude as a relevant biomarker and a significant effect of stimulation rate. The findings reinforce the use of ABR in CS investigation and provide insights for future studies.
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3
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ANA CLARA LOPES MARIZ
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Knowledge and attitude about children's hearing health in pregnant and postpartum women: an intervention guided by an educational video
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Advisor : ELIENE SILVA ARAUJO
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COMMITTEE MEMBERS :
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ELIENE SILVA ARAUJO
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HANNALICE GOTTSCHALCK CAVALCANTI
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MONIQUE RAMOS PASCHOAL DUTRA
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Data: Mar 7, 2025
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Show Abstract
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Introduction: Parents' knowledge about neonatal hearing screening (NHS), risk indicators for hearing impairment, and attitudes towards hearing loss directly influences child care. Educational videos have been effective in promoting hearing health. Objective: To validate an educational video on child hearing health and assess its impact on the knowledge and attitudes of pregnant women and puerperal woman. Method: The dissertation is structured into two articles. The first is a descriptive study aimed at validating a video as a tool for education in child hearing health. Initially, the video validation was conducted with five specialists, and in the second stage, 50 mothers evaluated their satisfaction with the video using a standardized questionnaire and the Net Promoter Score (NPS). The second study consists of a triple-blind randomized clinical trial, seeking to compare the impact of the educational intervention on child hearing health on the level of knowledge and information retention during pregnancy and the postpartum period. The study involved 60 pregnant women and 80 puerperal woman, with each population divided into two randomized groups: 30 pregnant women and 40 puerperal woman in the intervention group (IG) and the same number from each population in the comparison group (CG). Participants were subjected to a questionnaire on knowledge and attitudes regarding child hearing health, both before and immediately after exposure to the educational video (targeted for IG or about breastfeeding for CG). To assess medium-term information retention, puerperal woman in the IG were re-evaluated with the questionnaire three months after the intervention. Results: In the first study, it was observed that the video was well evaluated from both the specialists' and the target population's perspectives, showing a tendency towards satisfaction with the educational tool used. Specific suggestions for video improvement were noted by the specialists, and 84.0% of the mothers would give positive feedback (promoters), while 14.0% were indifferent. In the second study, an increase in knowledge was observed for both pregnant women (p<0.001) and puerperal woman (p<0.001) when comparing pre- and post-intervention moments in the IG. The comparison between IG and CG post-intervention demonstrated greater knowledge for the groups subjected to the intervention in both populations (p<0.001). On the other hand, when comparing the amount of information assimilated between pregnant women and puerperal woman, no difference was found (p=0.686), indicating that mothers were able to assimilate the knowledge conveyed at both moments of motherhood. Furthermore, for the IG of puerperal woman, there was no difference between knowledge immediately post-intervention and three months after the intervention (p=0.090). Conclusion: The educational video "Hearing Pills" was validated as an effective tool for education in child hearing health. In the first study, specialists and the target population positively evaluated the material, highlighting its appropriateness and relevance. In the second study, it was found that the video significantly increased knowledge on the topic among pregnant women and puerperal woman, with medium-term information retention. The findings indicate that both moments are opportune for educational intervention, enabling mothers to take an active role in their children's hearing health.
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4
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JOAO VICTOR SILVA DE BARROS LIMA
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Assessment Instruments for Word and Pseudoword Reading: Review and Applicability
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Advisor : CINTIA ALVES SALGADO AZONI
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COMMITTEE MEMBERS :
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ANA LUIZA GOMES PINTO NAVAS
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CINTIA ALVES SALGADO AZONI
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LUCIANA MENDONÇA ALVES
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RENATA MOUSINHO
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Data: Mar 10, 2025
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Show Abstract
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Objective: To map the literature for validated and non-validated instruments used to assess oral reading of words and pseudowords in schoolchildren aged 6 to 14 (Study 1) and to study the psycholinguistic variables of a stimulus bank to be used as an assessment tool for oral reading of words and pseudowords (Study 2). Method: For Study 1, a scoping review was conducted following PRISMA-ScR guidelines. The research question was developed using the "PCC" strategy (Population, Concept, and Context). Relevant studies were searched in the National Library of Medicine (PubMed), Scopus, Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, Education Resources Information Center (ERIC), and LiVIVO databases, using terms in Portuguese, Spanish, and English, depending on the database. Studies that used assessment and/or monitoring tools for oral reading of words and pseudowords in schoolchildren aged 6 to 14 years and 11 months, in clinical or educational settings, were included. For Study 2, the Fluency IDB Portuguese app was used to evaluate word and pseudoword decoding in 1st, 2nd, and 3rd-grade elementary school students. Results: In Study 1, the analysis of 16 included studies revealed 11 assessment tools, with stimuli varying in syllabic complexity, regularity, frequency, and length, including high- and low-frequency regular and irregular words, short and long words, and pseudowords following the language rules of the test. However, there was limited description of the validation of the instruments used in the studies. In Study 2, a progressive improvement in performance was observed across school years, with a reduction in errors and an increase in correct responses in the 2nd and 3rd grades. Additionally, factors such as the number and syllabic complexity of the stimuli significantly influenced student performance during schooling. Conclusion: In Study 1, 11 tools for assessing oral reading of words and pseudowords in schoolchildren were analyzed, highlighting the diversity of methods and the frequent lack of validation information, which may compromise the accuracy of the results. Emphasis was placed on speed, accuracy, and features such as syllabic complexity, essential for evaluating lexical and sublexical processing. The findings reinforce the need to develop and validate more reliable tools, contributing to more effective educational policies and interventions. In Study 2, the results indicated that reading performance improves with school progression, influenced by syllabic complexity and lexical familiarity. Younger children struggle more with complex words, while older children perform better, suggesting that reading fluency depends on the development of phonological and orthographic skills. Pseudowords are harder to read than real words, emphasizing the importance of lexical familiarity. The results underscore the need to consider syllabic complexity and school grade in assessments, interventions, and teaching materials, promoting an appropriate progression in reading instruction.
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5
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JADSON STHEFERSON DUTRA ALVES
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Obtaining Validity Evidence for the 'Degluto': A Bedside Swallowing Assessment Instrument
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Advisor : HIPOLITO VIRGILIO MAGALHAES JUNIOR
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COMMITTEE MEMBERS :
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ANNA ALICE FIGUEIRÊDO DE ALMEIDA
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HIPOLITO VIRGILIO MAGALHAES JUNIOR
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LICA ARAKAWA SUGUENO
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Data: Mar 10, 2025
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Show Abstract
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Oropharyngeal dysphagia is a prevalent condition in various clinical populations and can lead to complications such as malnutrition, dehydration, and aspiration pneumonia. Structured clinical assessment is essential for the proper management of dysphagia, requiring reliable and validated instruments. Given the need for a protocol adapted to the Brazilian reality, the DEGLUTO: Swallowing Assessment Instrument at the Bedside was developed, and its validation process is the focus of this dissertation. This is a methodological study divided into two phases. The first phase involved obtaining evidence of validity based on content, conducted through the Delphi method, with the participation of 13 dysphagia expert judges. The instrument's items were analyzed for relevance, clarity, and alignment with the evaluated construct. Seven items were removed, and one was reformulated, resulting in a preliminary version with 21 items. The second phase consisted of obtaining evidence of validity based on response processes through the application of the instrument by eight speech-language pathologists in hospital and outpatient settings. The professionals assessed the clarity and applicability of the items, as well as patients' understanding during the evaluation. Statistical analysis included the Content Validity Index (CVI), the Content Validity Coefficient (CVC), and the Kappa coefficient to assess agreement among raters. The results demonstrated high agreement for most items, except for one, which was removed, leading to the preliminary final version of DEGLUTO with 20 items. The study provided evidence that the instrument has clarity, relevance, and clinical applicability, contributing to the qualification of oropharyngeal dysphagia assessment. The findings support the continuation of the validation process, focusing on the analysis of the instrument’s internal structure and psychometric properties.
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6
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RHADIMYLLA NÁGILA PEREIRA
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ANALYSIS OF THE APPLICABILITY OF A LANGUAGE EVALUATION PROTOCOL VIA TELECONSULTATION FOR CHILDREN AT RISK AND DIAGNOSED WITH HEARING IMPAIRMENT
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Advisor : JOSELI SOARES BRAZOROTTO
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COMMITTEE MEMBERS :
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JOSELI SOARES BRAZOROTTO
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ANA MANHANI CACERES
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ADRIANE LIMA MORTARI MORET
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Data: Mar 28, 2025
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Show Abstract
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: Introduction: The unequal distribution of specialized professionals has spurred research in digital health to address the needs of oral language care in childhood, given that language delays are common complaints during this period. In this sense, this dissertation, composed of two research articles presented below, aimed to contribute to the field. Article 1: A scoping review investigated: “Which instruments are applicable for screening and assessing oral language in early childhood using digital health?” Studies were included if they utilized screening and assessment tests for oral language via teleconsultation, applications, and web-based tools, without restrictions on time, language, or ethnicity, in clinical, educational, and non-clinical settings. The databases consulted were PubMed, Web of Science, LILACS, Embase, and Scopus, in addition to gray literature via Google Scholar and ProQuest Dissertations and Theses. Out of 2,435 studies identified, 20 comprised the final sample. Eleven studies evaluated language skills screening and nine investigated digital language assessment. Fourteen studies adapted previously validated in-person tests to an online format; four developed specific teleconsultation tools, and two conducted synchronous or asynchronous observations without defined protocols. Most research was conducted in clinical settings with speech-language pathologists, although community health workers also participated in some studies. Videoconferencing was the most frequently used digital modality. The findings of this review reinforce the feasibility of telehealth for screening and assessing oral language, highlighting the need for further research to consolidate evidence-based practice in teleaudiology Article 2: This prospective clinical study, approved by an Institutional Ethics Committee (protocol no. 6.754.773), involved 12 children of both sexes, aged between 21 and 74 months. Of these, seven had bilateral sensorineural hearing loss ranging from moderate to profound, and five exhibited language alterations without confirmed hearing loss. All were evaluated using the Behavioral Observation Protocol (PROC), administered both remotely and in person by trained, blinded researchers. Agreement between scores obtained in each session was assessed using the intraclass correlation coefficient (ICC) and the Kappa index, comparing in-person and remote evaluations. Results: In the hearing-impaired group, the ICC for the overall score was 0.964 (p ≤ 0.05), and in the at-risk group, it was 0.888 (p ≤ 0.05), with a Kappa of 1.0 (p ≤ 0.05) for both groups. In the at-risk group, variable ICCs were observed when analyzing the individual sections of the PROC separately. Conclusion: Language assessment via synchronous teleconsultation using the PROC demonstrated clinical applicability in the studied population.
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7
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MIRELLY DANGLES DE OLIVEIRA FERREIRA
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FAMILY LITERACY PRACTICES FOR PRESCHOOLERS
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Advisor : CINTIA ALVES SALGADO AZONI
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COMMITTEE MEMBERS :
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CINTIA ALVES SALGADO AZONI
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Julia Beatriz Lopes Silva
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VANESSA DE OLIVEIRA MARTINS REIS
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Data: Mar 28, 2025
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Show Abstract
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Introduction: Family literacy is a construct of practices that includes all the resources, experiences and supports related to skills that promote children's development at home, including the ways in which they engage in literacy activities with other family members. When thinking about the importance for learning, family literacy practices can shape learning development, including in the areas of vocabulary, letter knowledge and reading comprehension. Objective: To analyze family literacy practices in preschool children and their impact on children with developmental risks. Methods: This is a two-part study: (1) a scoping review reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR); (2) a longitudinal, prospective and qualitative study that will be carried out between August 2024 and January 2025. The study population consisted of 8 children of both genders, aged between 15 months and 2 years and 6 months. Results: (1) 29 studies were included in the final synthesis of the scoping review, which revealed a predominance of informal practices. Among the activities carried out, the most cited was reading books, followed by shared reading. (2) When it came to analyzing the effectiveness of family literacy practices, the results showed that in communication skills, the children performed below expectations in the pre-intervention assessment and post-intervention progress. Conclusion: Based on the findings, it was observed that the literacy practices of the Conta pra Mim Program were beneficial for the oral language development of children at risk of development.
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8
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BEATRIZ DE SOUZA DOS REIS FRANCA
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Early identification of difficulties in learning to read
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Advisor : CINTIA ALVES SALGADO AZONI
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COMMITTEE MEMBERS :
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CINTIA ALVES SALGADO AZONI
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KARINNA VERISSIMO MEIRA TAVEIRA
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PATRICIA ABREU PINHEIRO CRENITTE
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Data: Apr 2, 2025
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Show Abstract
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Objective: To map and analyze screening instruments to identify risks of reading difficulties and disorders in preschool and school-aged children in clinical and educational contexts (article 1) and to investigate initial evidence of validity of the Brazilian version of the SPRouT instrument for screening phonological processing in preschool and school-aged children. Method: Scoping review conducted according to the PRISMA-ScR guidelines. The search was carried out in the SciELO, PubMed, LILACS, ERIC, Google Scholar and Web of Science databases, including studies on the construction, validation and practical application of the instruments (article 1). The second study included a pilot validation, descriptive and analytical stage, carried out in a private school in Brazil with children between 4 and 8 years old, including participants with and without oral and written language complaints (article 2). Results: The analysis of 40 studies identified 32 screening instruments. The review pointed out gaps in the psychometric validation and accessibility of the instruments, which limits their application (article 1). Article 2, in turn, revealed significant negative correlations between the SPRouT and other instruments for assessing phonological processing. Conclusion: Although there are a variety of instruments for screening for reading difficulties, significant challenges, such as accessibility and psychometric validity, restrict their application in different contexts (article 1). The SPRouT, in turn, proved to be particularly effective in predicting performance in tasks associated with phonological processing, providing preliminary evidence of validity and highlighting its potential as a promising tool for the early identification of risk for reading difficulties (article 2).
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9
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KARINE CHRISTINE GUSMÃO DE FREITAS CALHEIROS
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Vestibular dysfunction and postural changes in the pediatric population with congenital cytomegalovirus: a systematic review
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Advisor : ERIKA BARIONI MANTELLO
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COMMITTEE MEMBERS :
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ADRIANA RIBEIRO TAVARES ANASTASIO
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ERIKA BARIONI MANTELLO
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KARINNA VERISSIMO MEIRA TAVEIRA
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SHEILA ANDREOLI BALEN
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Data: Jun 17, 2025
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Show Abstract
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Congenital cytomegalovirus (CMV) is considered the most common etiology of congenital infection and its main sequela is sensorineural hearing loss. Considering the prevalence of sensorineural hearing loss in this population and the anatomical proximity of the cochlear and vestibular organs in the inner ear, vestibular disorders may also occur in children affected by congenital CMV infection. This study aimed to verify the presence of vestibular alterations and postural balance disorders in the pediatric population with congenital CMV infection. This is a systematic review conducted and reported according to PRISMA and registered in the International prospective register of systematic reviews- PROSPERO, under registration CRD42024549387. Five electronic databases (Embase, LILACS, PubMed/MEDLINE, Scopus and Web of Science) were searched, in addition to the gray literature (Google Scholar and ProQuest Dissertations and Theses). The following inclusion criteria were used: studies conducted in children aged 0 to 12 years, diagnosed with congenital CMV infection, performed through urine or saliva samples in the first 21 days of life, neonatal blood samples, serological tests or molecular tests; articles that addressed the assessment of vestibular function and body balance, and that compared symptomatic groups with asymptomatic groups and/or with healthy children. A metaanalysis was performed to estimate the association between vestibular alterations and cytomegalovirus, as well as the combined proportion of these alterations. A randomeffects model was used and subgroup analyses were performed according to the presence of symptoms. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist, and the certainty of the evidence was assessed using the GRADE tool. Only articles from randomized clinical trials and observational studies were selected. The search in the databases resulted in the identification of 2,840 studies and, subsequently, eight observational articles were considered eligible for qualitative synthesis. All included articles reported vestibular and/or body balance alterations in the group with congenital CMV infection. The meta-analysis indicated an approximately ten-fold higher risk of manifestation of vestibular alterations in this group compared to the control group (95% CI: 2.42–40.29). The analysis of the risk of bias identified that most of the studies were of moderate/high quality. The certainty of the evidence was considered very low according to the GRADE tool. In addition, there was a higher frequency of alterations in children with symptomatic than asymptomatic congenital CMV infection. Among the included studies, 50% were cohort studies and 50% were case-control studies; 100% were published in English; the sample size ranged from 24 to 185 children with congenital CMV infection, aged between zero and 11 years. The most commonly used tests were VEMP and vHIT. It is concluded that there is an approximately ten-fold higher risk of children with congenital CMV infection presenting vestibular alterations, compared to the control group. Furthermore, the estimate of the combined proportion of vestibular alterations was higher in symptomatic individuals. Similarly, children with symptomatic congenital CMV infection showed higher rates of alteration in postural balance tasks, compared to the groups with asymptomatic congenital CMV infection and the control group, in the included studies.
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10
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KAMILLA MARIA ALVES
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Socioeconomic status and language development in children born during the COVID-19 pandemic
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Advisor : ANA MANHANI CACERES
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COMMITTEE MEMBERS :
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ANA MANHANI CACERES
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LILIANE PERROUD MIILHER
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MARINA LEITE PUGLISI
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Data: Sep 23, 2025
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Show Abstract
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The COVID-19 pandemic, in addition to requiring isolation and social distancing, has sparked debate about how different socioeconomic conditions can impact child development in different ways. Several studies indicate that socioeconomic conditions are related to language development in early childhood. However, different measures are considered to characterise socioeconomic status, such as maternal education and family income, without a consensus on which would be the most appropriate for measuring this aspect. Given this scenario, this dissertation aimed to contribute to this debate in two complementary studies. The first study comprises a scoping review, whose objective is to investigate which measures are used to measure socioeconomic status in studies related to language development. This scoping review was conducted in accordance with the Joanna Briggs Institute proposal and described according to the PRISMA-SCR guidelines. The second study, which was observational and cross-sectional in nature, aimed to compare the linguistic performance of children born in the first year of the COVID-19 pandemic according to their socioeconomic status. Data collection was conducted in a school setting and included both the application of a parental questionnaire to characterise socioeconomic status and family stimulation environment, and language assessment through standardised tests that evaluate phonological and expressive vocabulary skills. The results obtained in this dissertation allow us to contribute to the scientific debate, as well as providing reflections on clinical practice in the area of child language, whether in a clinical setting or in spaces designed to stimulate language development and social interaction.
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11
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LARA LOUISE PINTO CAMARA
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Neural coding of speech sounds in infants with congenital cytomegalovirus and normal-hearing adults
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Advisor : SHEILA ANDREOLI BALEN
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COMMITTEE MEMBERS :
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ALINE TENORIO LINS CARNAUBA
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MILAINE DOMINICI SANFINS
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SHEILA ANDREOLI BALEN
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Data: Sep 23, 2025
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Show Abstract
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This dissertation aimed to compare the neural pattern of speech decoding in normal-hearing adults under different acoustic stimulus presentation conditions and to investigate the influence of cytomegalovirus (CMV) on the neural response to speech stimuli in infants. Two cross-sectional, prospective, observational studies were conducted. In Study 1, approved under No. 5,685,328, 28 normal-hearing adults (19 women) participated, all with Transient Evoked Otoacoustic Emissions present, and received the stimuli /da/ (170 ms, right ear) and /dao/ (binaural and monaural presentation in RE and LE). In Study 2, approved under No. 7,190,153, 256 infants were recruited, of whom 142 underwent urine collection for CMV PCR; 23 tested positive, and the final sample included four infants with cCMV, four with perinatal CMV, and four controls. Audiological evaluation included click, frequency-specific, and TEOAE Auditory Brainstem Responses. FFR data were analyzed in the time and frequency domains using the Kruskal-Wallis test with a 5% significance level. In Study 1, the /da/ stimulus showed a mean neural delay of 9.34 ms (±2.67), low cross-correlation (0.124 ±0.0291), high pitch strength (0.843 ±0.133), and a pitch error of 2.99 Hz (±1.20), with the spectral amplitude of F0 (0.085 ±0.0780) similar to mid harmonics (0.099 ±0.0710), both higher than high harmonics (0.028 ±0.0212). In the comparison of /dao/ presentation conditions, F0 was higher in the binaural condition in specific segments, but overall differences were not significant; SNR and neural lag did not vary, cross-correlation was greater in the LE than in the binaural condition, and pitch encoding was weaker in the RE. Comparing stimuli, /dao/ elicited faster responses (neural lag = 8.38 ms) and more robust mid- and high-harmonic amplitudes than /da/. In Study 2, no differences were observed between control, CMVc, and perinatal CMV groups in pre-stimulus RMS, neural lag, cross-correlation, SNR, pitch, or F0 amplitudes, although the /d/ segment showed higher high-harmonic amplitude in the perinatal CMV group, without robust significance in multiple comparisons. Overall, in normal-hearing adults, FFR demonstrated robust coding of F0 and mid harmonics, lower stability for high harmonics, and subtle effects of stimulus type and presentation, with faster and more spectrally robust responses to /dao/, whereas in infants, congenital CMV did not affect global FFR measures in early life but perinatal CMV showed indications of differential modulation in high-harmonic encoding, highlighting FFR’s potential as a clinical research tool and the need for larger, longitudinal studies to clarify CMV’s impact on auditory neurodevelopment.
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12
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ANNE KAROLINE WILLMER DE MORAIS
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Pragmatic profile of children with language complaints born into a social distancing context
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Advisor : ANA MANHANI CACERES
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COMMITTEE MEMBERS :
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ANA MANHANI CACERES
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JULIANA IZIDRO BALESTRO
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NOEMI TAKIUCHI
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Data: Sep 24, 2025
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Show Abstract
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Pragmatics relates to the functional use of language in social contexts. The social distancing imposed during the COVID-19 pandemic have significantly impacted the interaction and socialisation of a significant portion of the population. This impact may affect the development of communication skills in children born during this period, as their opportunities for social interaction and communication partners have been reduced. Considering this context, the aim of this dissertation was to investigate the pragmatic profile of children born during the context of social distancing and who present complaints related to language development. The study is cross-sectional and was conducted at the Speech Therapy Teaching Clinic of the Federal University of Rio Grande do Norte. A sample of 28 children, of both sexes, aged between 29 and 40 months, underwent a battery of assessments. This battery involved a questionnaire to characterise socioeconomic status and family environment, the language subscale of the Bayley III Scales, the Pragmatics section of the ABFW infant language test, and the Parent Observation of Social Interaction (POSI) section of the Survey of Wellbeing of Young Children (SWYC) protocol. The dissertation is structured into two complementary articles, resulting from analyses derived from this data collection. The first article investigated the concordance between the presence of risk for delayed language development (assessed by Bayley III) and indicators of social interaction difficulties (assessed by POSI-SWYC). The second article characterised the functional communication profile (ABFW Pragmatics) and related this profile to receptive and expressive communicative performance assessed by Bayley III.
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13
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LUZIMARA GLAUCIA OLIVEIRA RODRIGUES
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Stuttering at school: developing educational resource for teachers
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Advisor : ANA MANHANI CACERES
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COMMITTEE MEMBERS :
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RACHEL CASSIANO DE SOUSA
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ANA MANHANI CACERES
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DENISE BRANDÃO DE OLIVEIRA E BRITTO
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JULIA BIANCALANA COSTA
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Data: Sep 29, 2025
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Show Abstract
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Knowledge about stuttering and the appropriate behavior of teachers towards students who stutter is fundamental for the inclusion and good academic development of these students. With the aim of contributing to this topic, this master's thesis involved conducting a scoping review and subsequently developing educational material for teachers about stuttering. The scope review was conducted in accordance with the Joanna Briggs Institute proposal and described according to the PRISMA-ScR guidelines. The acronym PCC (Population, Concept, Context) was used, considering teachers as the population, knowledge and attitudes about stuttering as the central concept, and schools as the contexts of application. After the identification, selection, and eligibility analysis stages, 50 articles were included. In summary, the review indicated that, although the first publications predate the 1980s and there are publications in countries on different continents, teachers' knowledge and attitudes toward stuttering are not always adequate, which highlights the need for actions aimed at training teachers, either during their academic training or when they are already working. Based on this finding, educational material was developed for teachers in early childhood education and elementary school. This material is based on Knowles' principles for adult learning and proposes learning objectives in accordance with Bloom. This educational material aims to broaden understanding of stuttering and offer practical support for managing this communication disorder in the classroom. It is planned to be offered as a training course on a virtual learning platform, developed based on the ADDIE model, and will be submitted in the future for content validation, implementation, and evaluation. Thus, this dissertation seeks to bring scientific knowledge closer to the reality of schools, promoting more inclusive teaching practices and the creation of a learning environment that respects and supports people who stutter.
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14
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RANIELLY NÓBREGA DE OLIVEIRA
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AGREEMENT BETWEEN HEARING SCREENING PROCEDURES WITH THE DIGITS-IN-NOISE TEST (DIN) IN STUDENTS.
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Advisor : SHEILA ANDREOLI BALEN
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COMMITTEE MEMBERS :
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SHEILA ANDREOLI BALEN
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ARYELLY DAYANE DA SILVA NUNES ARAÚJO
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HANNALICE GOTTSCHALCK CAVALCANTI
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Ademir Antonio Comerlatto Junior
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Data: Dec 1, 2025
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Show Abstract
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Introduction: Identifying hearing loss in students is essential to ensure adequate educational and social development. Objective: To assess the agreement between auditory screening procedures and the Hearing-in-Noise Test (HINT) adapted as the Digits-in-Noise Test (DIN) in students. Method: This was a cross-sectional study conducted with 83 students from the Federal Institute of Rio Grande do Norte – Parnamirim Campus (52.2% female; 15 to 45 years old; mean age = 19.79 years), who underwent audiometric screening, transient-evoked otoacoustic emissions (TEOAE) screening, distortion product otoacoustic emissions (DPOAE) screening, tympanometric screening, and the Digits-in-Noise Test (DIN) in diotic and antiphasic modes. The DIN was administered via an online link on a smartphone using headphones, following an automated adaptive procedure, with cut-off points of –6.7 dB SNR (diotic) and –11 dB SNR (antiphasic). Agreement between procedures was analyzed using Fleiss’ Kappa and Cohen’s Kappa indices. Results: The diotic DIN showed the highest pass rate (98.80%), followed by the antiphasic DIN and DPOAEs (91.57%). The highest failure rate occurred in the TEOAEs (42.17%). Overall agreement between procedures was low (Fleiss’ kappa = –0.20), and pairwise agreement ranged from –0.02 to 0.34, indicating minimal to slight agreement among tests, with the highest agreement observed between tympanometry and DPOAEs. Conclusion: The DIN, particularly in the antiphasic mode, shows greater agreement with otoacoustic emissions in failure outcomes. Nevertheless, the sample size and differences in the distribution of outcomes may have limited the results. The DIN is a functional and promising tool for identifying hearing difficulties related to speech-in-noise recognition, although it does not replace traditional methods. The combination of different procedures contributes to a more sensitive hearing screening process among high school students.
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