Banca de DEFESA: FRANCIMAR LOPES DE SOUSA JUNIOR

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : FRANCIMAR LOPES DE SOUSA JUNIOR
DATE: 21/10/2022
TIME: 14:00
LOCAL: videoconferência
TITLE:

In vitro biological activity of copper and zinc complexes with vanilloid results: Characterization, superoxide generation assay, anticancer and antiparasitic activities.

KEY WORDS:

Complexes, Copper, Zinc, anticancer activity, antiparasitic activity.

PAGES: 100
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Metallic compounds containing vanilloid derivatives have gained interest in medicinal inorganic chemistry, due to the biological properties of this class of ligands, having as an example the ability to generate specific reactive oxygen (SRO). In this context, the present work aims to synthesize and characterize complexes of the type [M(phen)(L)2], where M=Cu2+ and Zn2+, and L=o-vanillin (ovan) and ovani, in which the latter is a schiff base derived from the reaction of o-vanillin with isoniazid. In addition, the [Cu(phen)(ovan)2](3) and [Zn(phen)(ovan)2] (4) complexes were tested against AGS and HeLa cancer strains, as well as Tryponosomacruzi strains. From the vibrational spectra of the complexes [M(phen)(ovan)2], the mode of coordination of the ovan was determined by the variation of the energy of the carbonyl band, in addition, for the compounds [M(phen)(ovani)2], it was observed the presence of the hydrazide C=O band at 1709 cm-1 and the imine band (C=N) around 1630 cm-1, which are indicative of the formation of the Schiff base. From the study of cyclic voltammetry, it was observed that the [Cu(phen)(ovan)2], presented an E1/2 of -171 mV, demonstrating within the redox range of the biological medium, with this, the test of the tetrazolium-nitroblue chloride (NBT), using glutathione as a reducing agent, showed a positive response to the formation of O2-. Complex (3) was more effective in both strains with IC50 of 6.19 and 5.63 µM, for AGS and HeLa respectively. Regarding the antiparasitic test, a dose-dependent behavior was observed for both compounds, obtaining an inhibitory concentration of 5.03 for (3) and 108.40 µM for (4) respectively.

COMMITTEE MEMBERS:
Presidente - 348475 - DJALMA RIBEIRO DA SILVA
Interno - 1198847 - JOSE LUIS CARDOZO FONSECA
Externo ao Programa - 1945343 - FRANCISCO ORDELEI NASCIMENTO DA SILVA - UFRNExterno ao Programa - 1715109 - DANIEL DE LIMA PONTES - UFRNExterno à Instituição - JOSÉ CLAYSTON MELO PEREIRA - UNESP
Externa à Instituição - VERONICA DA SILVA OLIVEIRA - UFRN