Derivatives of acylated monomeric phloroglucinols are predominant secondary metabolites in the genus Hypericum and have an acyl group directly connected to the THB nucleus, in addition to very commonly also having prenyl and geranyl substituents. The origin of these compounds shows that the carbonyl unit is bioenergetically favored, this is because phloroglucinols come from a biosynthetic route where the THB nucleus is biosynthesized by the acetate-malonate pathway, being susceptible to cyclization and oxidation. Due to its structural variability and associated diverse biological activities, there is an interest in new studies and reviews that aim to explore the topic in a more specific way. For this review, a survey of data from the period between 1965 and 2022 was carried out on the platforms Google Scholar, CAPES Periodicals, Science Direct and ScienceFinder, considering as inclusion criteria compounds of the class of monomeric acylphloroglucinols, also called acetophenones, from the aforementioned biosynthesis , relating to the different species of plants where they were isolated from their extracts and cataloged structurally and biologically. Among the main biological activities found, the following stand out: anti-inflammatory, antibacterial and cytotoxic. 1H and 13C NMR (nuclear magnetic resonance) data served as a basis for the chemical analysis of the compounds and their grouping into classes of monocyclic and polycyclic monomers with prenyl and geranyl substitutions.