Banca de QUALIFICAÇÃO: FRANCIMAR LOPES DE SOUSA JUNIOR

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : FRANCIMAR LOPES DE SOUSA JUNIOR
DATE: 09/09/2022
TIME: 14:00
LOCAL: videoconferência
TITLE:

In vitro biological activity of copper and zinc complexes with vanilloid results: Characterization, superoxide generation assay, anticancer and antiparasitic activities.

KEY WORDS:

Complexes, Copper, Zinc, anticancer activity, antiparasitic activity.

PAGES: 90
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Metallic compounds containing vanilloid derivatives have gained interest in medicinal inorganic chemistry, due to the biological properties of this class of ligands, mainly due to the ability to generate specific reactive oxygen (ROS). In this context, the present work aims to synthesize and characterize complexes of the type [M(phen)(L)2], where M=Cu2+ and Zn2+, and L=o-vanillin (ovan) and ovani, in which the latter is a schiff base derived from the reaction of o-vanillin with isoniazid. From the vibrational spectra of the complexes [M(phen)(ovan)2], the mode of coordination of the ovan was determined by the variation of the energy of the carbonyl band, in addition, for the compounds [M(phen)(ovani)2], it was observed the presence of the hydrazide C=O band at 1709 cm-1 and the imine band (C=N) around 1630 cm-1, Which indicates the formation of the Schiff base. From the study of cyclic voltammetry, it was observed that [Cu(phen)(ovan)2], presented an E1/2 of -171 mV, demonstrating that it is within the redox range of the biological medium, with this, it was performed nitro-blue tetrazolium chloride (NBT) test, using glutathione as a reducing agent, showed a positive response for the formation of O2-. The compounds [M(phen)(ovan)2] were tested against cervical (HeLa) and gastric (AGS) adenocarcinoma cell lines, with the most effective Cu2+ complex in both lines with IC50 of 6.19 and 5.63 µM.

COMMITTEE MEMBERS:
Externo ao Programa - 1715109 - DANIEL DE LIMA PONTES - UFRNPresidente - 348475 - DJALMA RIBEIRO DA SILVA
Externo ao Programa - 1945343 - FRANCISCO ORDELEI NASCIMENTO DA SILVA - UFRNExterna à Instituição - VERONICA DA SILVA OLIVEIRA - UFRN