Banca de QUALIFICAÇÃO: LALYSON MATHEUS LEMOS RODRIGUES DE SOUZA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LALYSON MATHEUS LEMOS RODRIGUES DE SOUZA
DATE: 16/12/2021
TIME: 14:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

: New phenantroline complexes of copper and cobalt with monastrol derivatives: synthesis, spectroscopic and electrochemical study.

KEY WORDS:

Bioinorganic. Cobalt complexes. Copper complexes. Monastrol derivatives.

PAGES: 145
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Cobalt and copper complexes stand out as promising systems in the treatment of cancer, both due to the low toxicity of these metals in the biological environment, as well as the magnetic and electrochemical properties, making it quite interesting from the biological and medicinal point of view. In addition to metals, there is also a search for systems with bioactive ligands, for example monastrol derivatives, which can together with metal form structures with properties highly relevant for cancer treatment. Thus, this work is presented, with the aim of contributing to the inorganic chemistry of Co(II) and Cu (II) systems, with the synthesis and spectroscopic and electrochemical characterization of new complexes with monastrol derivatives in systems [M(phen)(S-Cros)₂] and [M(phen)(O-Cros)₂], where  M = Co(II) e Cu(II), phen corresponds to 1,10-fenantrolina, S-Cros = ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, and O-Cros = ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. All complexes were synthesized by adding to the precursor complexes [Co(phen)Cl₂] and [Cu(phen)Cl₂] the ligands S-Cros and O-Cros, in the ratio of 1:2 from precursor to ligand, using water as solvent, adjusting the pH to 11. The ligands were initially characterized by NMR 1H spectroscopy in DMSO-d6, presenting good correlation between the chemical shifts and the hydrogens in the molecules of S-Cros and O-Cros. Analyzing the vibrational spectra obtained in KBr pellets on the [M(phen)(S-Cros)₂] and [M(phen)(O-Cros)₂] systems, phenantroline bands in the complexes displays near the region of 1427, 854 and 723 cm^-1, in addition to the S-Cros ligand bands, with stretching modes at 1692, 1202, 1029 and 751 cm^-1 and vibrational modes of the O-Cros  at 1696,1642, 1226 and 1023 cm^-1. The electronic spectra of the complexes [M(phen)(S-Cros)₂] and [M(phen)(O-Cros)₂] obtained in metanol, presented intraligand and intrametal bands, where in the ultraviolet region there are the bands of phenanthroline ligand, already the ligand S-Cros display a band at 304 nm, and the ligand O-Cros display a band at 285 nm. Additionally to these transitions, all complexes presented three d-d bands, due to the coordination environment of the complexes. Cyclic voltamograms of all complexes were obtained in TBAP dissolved in DMSO, presenting quasi reversible processes for both metals, for cobalt the processes are Co¹⁺/Co²⁺ and Co²⁺/Co³⁺ and for Cu¹⁺/Cu²⁺ for copper in the systems [M(phen)(S-Cros)₂] and [M(phen)(O-Cros)₂], besides there are oxireduction processes of the S-cros and O-cros

BANKING MEMBERS:
Presidente - 349770 - DULCE MARIA DE ARAUJO MELO
Externo ao Programa - 1715109 - DANIEL DE LIMA PONTES
Externo ao Programa - 1945343 - FRANCISCO ORDELEI NASCIMENTO DA SILVA