Banca de DEFESA: LUCAS HILÁRIO NOGUEIRA DE SOUSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LUCAS HILÁRIO NOGUEIRA DE SOUSA
DATE: 17/09/2021
TIME: 14:00
LOCAL: Vídeoconferência
TITLE:

Literature review on the genus Callyspongia and chemical analysis of the species Callyspongia vaginalis.

KEY WORDS:

demosponges, Callyspongia, C. vaginalis, polyacetylenes, anticancer, ceramide.

PAGES: 185
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

The genus Callyspongia (Callyspongiidae) is a group of demosponges including 261 described species and approximately 180 accepted by taxonomist’s review. The marine organisms of Callyspongia are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic and the East Pacific Oceans. The interest in the genus Callyspongia is because it is a source of bioactive compounds. In this review, we group the chemical information about the secondary metabolites isolated from the genus Callyspongia, as well as studies of the biological activity of these compounds. Through NMR data, a total of 212 metabolites were identified from genus Callyspongia (15 species and Callyspongia sp.), of which 103 compounds are categorized as polyacetylenes and lipids. Beside these, benzenoids, alkaloids, indol derivatives, diazepine, diketopiperazines, dipeptides, amphiphilic diacid, naphthopyrone, macrolide, polyketides, dihydrofurans, benzofuran, nucleosides, cyclic peptides, cyclic depsipeptides were isolated in the genus. 109 molecules have been reported with some bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes correspond to the largest class of bioactive metabolites of the genus and the results are in accordance with the relevance of the metabolites for anticancer action. In addition, a chemical prospection of the hexane fraction from ethanol extract of the specie Callyspongia vaginalis carried out in the present paper allowed the isolation and identification by spectroscopic analysis techniques, including 1D and 2D NMR, of two substances: β-sitosterol, widely isolated in plants, but reported one time in genus, and a ceramide, reported here for the first time in the genus Callyspongia. In addition, GC-MS analysis allowed the identification of four unsaponifiable compounds (stigmasterol, brassicasterol

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Interno - 2276354 - LEANDRO DE SANTIS FERREIRA
Presidente - 1569526 - RENATA MENDONÇA ARAUJO