Banca de QUALIFICAÇÃO: MARIA APARECIDA AIRES DE LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA APARECIDA AIRES DE LIMA
DATE: 12/03/2021
TIME: 14:00
LOCAL: VIDEO CONFERENCIA
TITLE:

Synthesis and characterization of tetracyan complexes - Na₂[Fe(CN)₄(L)₂] - in which L are the Pyrazinamide and Isoniazid ligands

KEY WORDS:

Iron complexes. Tetracians. Isoniazid. Pyrazinamide

PAGES: 72
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

The growing number of bacteria resistant to conventional antibiotics has led the scientific community to seek more effective, selective drugs that cause less side effects. In this context, the development of coordination compounds for pharmacological purposes has been a great resource in the fight against resistant microorganisms due to the coordination of metal cations to significantly alter the physiological profile of drugs; making them more active than the free binder, reducing side effects and leading to a reduction in microbial resistance. Given the above, the present work aims to synthesize and characterize iron complexes of the type Na₂[Fe(CN)₄(L)₂] in which L are the ligands, amino, pyrazinamide and isoniazid. The tetracians were obtained from the precursor compound NAT211 - Na₂[Fe(CN)₄(NH₃)₂] - dissolved in water followed by the addition of the binders, under stirring. Through vibrational spectroscopy in the infrared region, it was possible to detect the characteristic signals of the ligands coordinated to the metallic center, such as: cyan in the region between 2011 and 2094 cm^-1; amino at 3288 cm^-1; pyrazinamide in the range of 3412 to 1477 cm^-1; and isoniazid from 3302 to 1554 cm^-1. The electronic spectra in the UV-Vis region of the complexes showed bands of the type, d-d at 439 nm for the precursor; 378 nm for the compound with the pyrazinamide linker (NAT212) and 303 nm for the complex with the isoniazid (NAT213). The cyanide charge transfer bands (MLCT) are observed between 218 and 210 nm in the synthesized compounds. The MLCT of the N-heterocyclic ligands appear in 494 and 442 nm referring to NAT212 and NAT213, in that order. The analysis of voltammograms showed the presence of only one redox pair, with half wave potentials (E1 / 2) at 105, 334 and 242 mV for compounds NAT211, NAT212 and NAT213, respectively, indicative of the redox pair Fe^III / Fe^II.

BANKING MEMBERS:
Interna - 349770 - DULCE MARIA DE ARAUJO MELO
Externo ao Programa - 1945343 - FRANCISCO ORDELEI NASCIMENTO DA SILVA
Presidente - 2087667 - TIAGO PINHEIRO BRAGA