Banca de DEFESA: ELMAR DAMASCENO JUNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ELMAR DAMASCENO JUNIOR
DATE: 08/02/2020
TIME: 14:00
LOCAL: Auditório do CCET
TITLE:

Application of palygorskite in pH-responsive release of tuberculostatic drugs

KEY WORDS:

tuberculosis, isoniazid, rifampicin, palygorskite, pH-responsive system.

PAGES: 140
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SPECIALTY: Separação
SUMMARY:

Tuberculosis (TB) is the second leading cause of death from worsening infection worldwide. This status is mainly due to therapeutic efficacy problems encountered in existing treatments. Isoniazid (INH) and rifampicin (RIF) are very effective first-line drugs in the treatment and prevention of TB. However, administration of these drugs may cause serious side effects such as peripheral neuropathy, hepatotoxicity, hematotoxicity and other adverse effects from prolonged use of these substances, which may result in discontinuation of treatment. Thus, it is necessary to search for new delivery systems for tuberculostatic drugs, in order to avoid unwanted adverse effects, protect the drug from degradation in the gastrointestinal tract, increase its bioavailability and, consequently, improve its therapeutic efficacy. The present work studied the obtaining of pH-responsive systems for INH and RIF, using palygorskite (PAL) as nanocarrier, a natural, abundant and low cost material. The incorporation process was evaluated through a factorial design in order to investigate the influence of some factors on drug adsorption. The experiment using the maximum concentration (0.075 mg / mL for INH and 0.125 for RIF), lower PAL mass (300 mg) and lower pH (pH 2) was the most efficient compared to the other experiments performed, resulting in a higher concentration. incorporated drug dose equivalent to 12.93 mg / g PAL for INH and 33.62 mg / g PAL for RIF. The results obtained by the characterization techniques employed (FTIR, XRD, TG/DTG, DSC, Zeta Potential, SEM and EDS) and by the application of kinetic models and adsorption isotherms confirmed the incorporation of the drugs in the clay mineral and helped to elucidate the mechanism of interaction between materials. Through in vitro release studies performed for isoniazid, it was possible to prove the efficacy of the pH-dependent system obtained for the drug. More than 60% of the dose was released into the intestinal medium (pH 6.8 and pH 7.4). The kinetic study showed that the zero-order model was the best fit to the experimental data, indicating that INH is released at a long time from the palygorskite.

BANKING MEMBERS:
Presidente - 348475 - DJALMA RIBEIRO DA SILVA
Interno - 1198847 - JOSE LUIS CARDOZO FONSECA
Externa ao Programa - 1412709 - NEDJA SUELY FERNANDES
Interna - 1308577 - SIBELE BERENICE CASTELLA PERGHER
Externo à Instituição - VERA R. LEOPOLDO CONSTANTINO - USP