Banca de QUALIFICAÇÃO: PAULO CÉSAR FRANÇA DA CÂMARA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : PAULO CÉSAR FRANÇA DA CÂMARA
DATA : 12/11/2019
HORA: 09:00
LOCAL: LAPET
TÍTULO:

OBTAINING BIOMATERIALS FROM TANNIN/GLYCOSAMINOGLYCANS-BASED DERIVATIVES FOR APPLICATIONS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE

PALAVRAS-CHAVES:

Polyelectrolyte multilayers, Glycosaminoglycans, Tannins, Scaffolds, Stem cells

PÁGINAS: 90
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Polímeros e Colóides
RESUMO:

Develop stable polysaccharide structures with biochemical and biomechanical properties used by extracellular matrix (ECM) is one of the goals of tissue engineering and regenerative medicine. Improve the biocompatibility of conventional materials through surface modification has been shown to be an effective way to enhance their biological response. We report a new class of layered surfaces to increase biocompatibility and cellular response of biomaterials using tanfloc and glycosaminoglycans (chondroitin sulfate or heparin) since these polymers possess inspired chemistry structures to those found in ECM. The construction of polyelectrolyte multilayers was monitored by Fourier Transform Surface Plasmon Resonance (FT-SPR). The surface properties were assessed by X-ray Excited Photoelectron Spectroscopy (XPS), Atomic Force Spectroscopy (AFM) and contact angle measurements. The response of human adipose-derived stem cells (ADSCs) was evaluated in vitro through cytocompatibility assays, adhesion and proliferation of the cells using fluorescence microscopy. The interactions of ADSCs with these new biomaterial surfaces demonstrate that these surface coatings exhibit good cytocompatibility and that they promote cell attachment and proliferation. These characteristics are very desirable for biocompatible coatings for applications such as tissue engineering scaffolds and orthopedic implants.

MEMBROS DA BANCA:
Externo ao Programa - 2220417 - CARLOS AUGUSTO GALVAO BARBOZA
Interno - 1198847 - JOSE LUIS CARDOZO FONSECA
Presidente - 1149440 - ROSANGELA DE CARVALHO BALABAN