Banca de DEFESA: DANIEL SEGUNDO XAVIER DA FONSECA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : DANIEL SEGUNDO XAVIER DA FONSECA
DATA : 06/09/2018
HORA: 09:00
LOCAL: Sala de conferência de vídeo da Maternidade Januário Cicco
TÍTULO:

CHEMICAL STUDY OF LIPID FRACTIONS AND ACETATE FRACTIONS OF MARINE SPONGES Agelas dispar, Chondrilla nucula, Aplisyna fulva, Desmapsamma anchorata and Topsentia ophiraphidites E ANTIFUNGAL ACTIVITY TEST OF LIPID FRACTIONS

PALAVRAS-CHAVES:

Marine sponges, Lipids, Fatty acids, Gas chromatography (GC-MS), antifungal activity

PÁGINAS: 96
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Química dos Produtos Naturais
RESUMO:

Fatty acids (AGs) are naturally occurring metabolites found in all parts of living things, and marine sponges have large amounts of GAs. Interest in these compounds arose in the 1970s, and has increased, since sponges have very rich chemical AGs, and are the source of a diverse variety of chemical structures. The study of spongy lipids is as important as other secondary metabolites. The structures were confirmed by gas chromatography coupled to GC-MS mass spectrometry through their methyl esters, using 2 series of GA standards and 4 libraries in addition to the fragmentation profile. Identification was performed through similarity and analysis of mass spectra. These results highlight the high capacity of AG synthesis by these organisms, being superior to other living organisms. Thus, the lipid profile of six sponges of the species Agelas dispar Chondrilla nucula, Topsentia ophiraphidites, Cinachyrela apion and Aplisyna fulva of the northeast coast of Brazil. The species Aplysina fulva, Topsentia ophiraphidites and Cinachyrella apion were investigated for the first time, and the species Agelas diapar, Chondrilla nucula and Desmapsamma anchorata were reexamined for their composition of fatty acids. The data revealed more than 100 fatty acids, some unheard of for the sponge species studied in this study, such as Hydroxylated acids, in Chondrilla nucula and Aplysina fulva. 4,8,12-Trimethyltridecanoic acid and 3,7,11,15-tetramethylhexadecanoic acid (phytanic) polymers known as isoprenoid acids have been identified. Among the unsaturates identified include acids with a substitution pattern Δ5.9, contribute significantly to the amount of polyunsaturated fatty acids of sponges, (5Z, 9Z) -23-methyl-5,9-tetracosadienoic acid being the only one to have branching with this replacement pattern. The present work also evaluated the antifungal activity of the lipid fractions by means of the microdilution test in broth, obtaining satisfactory results for the lipid fraction of the species Aplysina fulva.

MEMBROS DA BANCA:
Presidente - 1569526 - RENATA MENDONÇA ARAUJO
Interno - 2140775 - LIVIA NUNES CAVALCANTI
Externo ao Programa - 2276354 - LEANDRO DE SANTIS FERREIRA
Externo à Instituição - LILIAN GRACE DA SILVA SOLON - UNIFAP