Banca de DEFESA: TAIZA NAYARA DA SILVA CARIDADE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : TAIZA NAYARA DA SILVA CARIDADE
DATA : 27/07/2018
HORA: 09:30
LOCAL: Auditório do Química 3
TÍTULO:

PHYTOCHEMICAL AND BIOLOGICAL STUDY OF FOUR DIFFERENT SPECIES OF Waltheria GENUS

PALAVRAS-CHAVES:

Waltheria. Malvaceae. Flavonoids. Auranamide. Artemia salina. DPPH.

PÁGINAS: 120
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Química dos Produtos Naturais
RESUMO:

The genus Waltheria belongs to the family Malvaceae, which is composed of 243 genera and 4225 species distributed in different regions of the world, mainly in tropical regions of South America. Its popular use is vast, and its species are used in the treatment of ulcers, hemorrhoids , asthma, diarrhea, in addition to presenting high antioxidant, anticancer, anti-inflammatory and anticonvulsive activity. Species of this genus are rich in flavonoids, terpenes, alkaloids, cyclopeptides, among other secondary metabolites. The phytochemical study of the aerial parts and stem of different Waltheria species led to the isolation of a pentacyclic triterpene of lupan type, 3-oxolup-20 (29) -en-28-oic acid (betulonic acid), four flavonoids: 5- hydroxy-3,3,4,4-trimethoxyflavone, canferol-3-O-β-glucopyranoside, glycopyranoside and canferol-3-O-β-hydroxy-3,3 ', 4' (6 '' - cumaroyl) -glycopyranoside (tyloside), both unpublished for the species studied. In addition to the N-benzoyl-2-amino-3-phenylpropyl N-benzoyl-L-phenylalaninate dipeptide known as auranamide, unheard of for the genus studied. The study of dereplication of the studied strata showed that flavonoids are major metabolites in the species collected in the northeast, diverging from the study carried out in the south of the country, which may be related to the influence of abiotic factors. A preliminary toxicity test of the extracts with Artemia salina revealed the low toxicity of the studied species with LD50 of greater than 1000 μg / mL, in addition to high antioxidant activity against the DPPH radical, especially Waltheria douradinha, which presented superior activity to the other species studied.

MEMBROS DA BANCA:
Presidente - 1569526 - RENATA MENDONÇA ARAUJO
Interno - 2140775 - LIVIA NUNES CAVALCANTI
Externo à Instituição - ROSA VIRGÍNIA SOARES MAMEDE - UESPI