Banca de QUALIFICAÇÃO: LETÍCIA GRACYELLE ALEXANDRE COSTA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : LETÍCIA GRACYELLE ALEXANDRE COSTA
DATA : 04/12/2017
HORA: 10:00
LOCAL: Auditório do NUPPRAR
TÍTULO:

STUDY OF THE ELIMINATION OF ANTITUBERCULOSIS DRUGS IN HOSPITAL AND WASTEWATER SAMPLES USING LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROSCOPY WITH IONIZATION BY ELETROSPRAY (LC-ESI /MS/MS)

PALAVRAS-CHAVES:

Hospital effuent; Isoniazid; Rifampicin; Ethambutol; Pirazinamide; HPLC-DAD.

PÁGINAS: 90
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Analítica
ESPECIALIDADE: Análise de Traços e Química Ambiental
RESUMO:

Pharmaceuticals are the group of emerging contaminants that have been receiving the attention in recent years, with hospital effluents being the main source of introduction into the environment. The main concern related to the presence of these compounds in the environment is due to the development of bacterial resistance. The antibiotics stand out because of their intensive use, being able to highlight those that fight Tuberculosis (TB) considered one of the biggest health worldwide problems. The present study aimed at the development a methodology for the determination of Pirazinamide, Isoniazid, Rifampicin and Etambutol in hospital effluent samples using SPE - HPLC - DAD. A 2.1 mm x 100 mm C₁₈ chromatographic column was used; 3 μm. The mobile phase A was composed of an aqueous phase of 85% ammonium formate buffer 0.3 mol.L^-1 pH 5.0, 15% methanol and 0.005 mol.L^-1 of Cu²⁺ or 250 mg.L^-1 of CuSO₄.5H₂O, while the organic phase B consisted of methanol, 0.1% triethylamine and 0.2% formic acid.

MEMBROS DA BANCA:
Presidente - 348475 - DJALMA RIBEIRO DA SILVA
Interno - 347057 - TEREZA NEUMA DE CASTRO DANTAS
Externo à Instituição - ELISAMA VIEIRA DOS SANTOS - UFRN