Banca de DEFESA: SARAH POLLYANA DIAS DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : SARAH POLLYANA DIAS DOS SANTOS
DATA : 14/07/2016
HORA: 14:00
LOCAL: Auditório do Química 3
TÍTULO:

INDOLE ALKALOIDS OF aspidosperma pyrifolium: CHEMICAL STUDY AND DATA spectroscopic

PALAVRAS-CHAVES:

aspidospermine, cordifoline, β-carboline, Aspidosperma pyrifolium, ¹H e ¹3C RMN

PÁGINAS: 173
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Química dos Produtos Naturais
RESUMO:

The chemical study Aspidosperma pyrifolium Mart, using seed fractions and peel the fruit, allowed the isolation of the three compounds. From the hexane fraction of the fruit peel (APCF-H) was isolated triterpene betulinic acid, not previously reported in the peel of the fruit of A. pyrifolium. It was possible to isolate alkaloid plumerado pentacyclic Aspidospermina and two other compounds however, have not had their molecular structures elucidated yet, but data of 1H and 13C NMR indicated that have compatible structures -carbolines alkaloids isolated from the dichloromethane fraction of seeds (APSE-DCL). Evaluation of antioxidant activity by DPPH method of APSE-DCL fraction obtained a good antioxidant activity AA% maximum 83.68%, IC 50 133.4867 ± 2.22. The same fraction was evaluated for toxicity, considering that there was already reports of toxicity in leaves of A. pyriflium, proved on acute toxicity LC50 1.1524 seed with μg.mL-1 being considered toxic species with LC50 less than 1000 μg.mL-1. In this study it was possible to compile the data of 1H and 13C of 163 alkaloids reported in naturally occurring literature, the structural diversity and biological activity described for this class of compounds show a potential for development and optimization of their biological activities, and therefore strong candidates for drug discovery.

MEMBROS DA BANCA:
Externo à Instituição - DAYSE DAS NEVES MOREIRA - UFPB
Presidente - 1569526 - RENATA MENDONCA ARAUJO
Externo ao Programa - 1490222 - SILVANA MARIA ZUCOLOTTO LANGASSNER