Banca de QUALIFICAÇÃO: JOADIR HUMBERTO DA SILVA JUNIOR

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOADIR HUMBERTO DA SILVA JUNIOR
DATE: 17/03/2026
TIME: 08:30
LOCAL: Auditório - Química III
TITLE:

ANALYTICAL INSTRUMENTATION BASED ON OPEN SOURCE HARDWARE AND 3D PRINTING: DEVELOPMENT OF AN ACCESSORY FOR INFRARED REFLECTANCE AND ITS APPLICATION IN PHARMACEUTICAL QUALITY CONTROL.

KEY WORDS:

Open-Source Hardware; 3D Printing; Infrared Spectroscopy; Green Analytical Chemistry; MCR-ALS; Pharmaceutical Quality Control

PAGES: 80
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SPECIALTY: Instrumentação Analítica
SUMMARY:

The reliance on proprietary, high-cost analytical instrumentation imposes significant barriers to scientific research and quality control, particularly in resource-limited settings. In response, the Open-Source Hardware (OSH) movement and additive manufacturing (3D printing) have emerged as disruptive strategies for the democratization and customization of scientific tools ("lab-made"). This work proposes the development of a green, non-destructive, and low-cost analytical platform based on Infrared Specular Reflectance Spectroscopy (ERS-FTIR). The project was structured in two complementary stages. The first stage consisted of the design, manufacturing, and physical validation of a 3D-printed specular reflectance accessory. The device demonstrated dimensional precision and optical stability comparable to commercial accessories, validated through the determination of optical constants ( and ) of polymers and in situ kinetic monitoring of epoxy resin curing. To correct the optical distortions inherent to the technique, a Python algorithm based on the Kramers-Kronig Transform was developed. In the second stage, the analytical feasibility of the system was demonstrated in pharmaceutical quality control, aiming for the simultaneous quantification of Acetylsalicylic Acid (ASA) and its main degradation product, Salicylic Acid (SA), in tablets. The integration of the accessory with Multivariate Curve Resolution (MCR-ALS) allowed overcoming severe spectral overlap and the concentration discrepancy between the major drug and the trace impurity. The proposed method achieved quantification limits compliant with pharmacopeial requirements and presented accuracy statistically equivalent to the reference HPLC-DAD method. Results confirm that the integration of open hardware, additive manufacturing, and chemometrics enables the development of robust and accessible instrumentation, aligned with Industry 4.0 and Green Analytical Chemistry principles.

COMMITTEE MEMBERS:
Presidente - 2413537 - POLLYANA SOUZA CASTRO
Interna - 3420591 - ANA CAROLINA DE OLIVEIRA NEVES
Interna - 3390839 - SENDY MELISSA SANTOS DO NASCIMENTO