Banca de QUALIFICAÇÃO: CARLOS RANIERI COSTA BATISTA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : CARLOS RANIERI COSTA BATISTA
DATE: 09/12/2024
TIME: 14:00
LOCAL: videoconferência
TITLE:

MODIFIED RELEASE SYSTEM OF THE ANTICHAGASTIC BENZNIDAZOLE USING LAPONITE AS A NANOCARRIER.

KEY WORDS:

Modified release; medicine delivery; benznidazole; laponite; Eudragit ^Ⓡ S100

PAGES: 70
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SUMMARY:

Benznidazole (BNZ) is a medicine used to treat Chagas disease, which is considered neglected and victimizes thousands of people around the world. This substance has low solubility in gastrointestinal environments, which leads to low bioavailability of the drug in the body. A convenient alternative to improve treatment efficiency is the incorporation of the medicine into clays, forming a modified medicine delivery system. This way, there are better therapeutic effects and milder side effects. In this work, BNZ was incorporated into laponite (LAP), a synthetic clay that has a disc shape with a large specific area and highly ionic regions, using the fusion method. In this way, by capillarity the drug impregnated the LAP forming the hybrid (LAP + BNZ) that was coated with eudragitⓇ S100 to protect the drug from manipulation in acidic pH. This protection occurred through the evaporation of the solvent in which the drug was used. ethanol. The resulting product was characterized by X-ray Diffraction (XRD), X-ray Fluorescence (XRF), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetry (TG), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy (SEM-EDS). Through a study simulating stomach and intestinal pH, it was possible to verify that the modified system was efficient in the controlled release of the drug benznidazole, which gradually released around 89% of the drug over 12 hours. And through the kinetic study, it was evidenced that the model with the best fit was the Korsmeyer-Peppas model, which indicates that the release process of this drug is controlled by diffusion.

COMMITTEE MEMBERS:
Presidente - 2413537 - POLLYANA SOUZA CASTRO
Externa ao Programa - 1412709 - NEDJA SUELY FERNANDES - UFRNExterno à Instituição - JORGE LEANDRO AQUINO DE QUEIROZ - IFRN
Externa à Instituição - RAQUEL DE MELO BARBOSA - US