Pre-Exposure Prophylaxis (PREP) in the daily routine of Primary Health Care: Evidence from the experience in Natal-RN, Brazil.
Pre-Exposure Prophylaxis. HIV. Primary Health Care. Treatment Adherence and Compliance.
The HIV epidemic remains a global challenge, highlighting the need for effective prevention strategies such as Pre-Exposure Prophylaxis (PrEP). This study aims to investigate the adherence to and retention of PrEP users in a Primary Health Care Unit in the municipality of Natal, state of Rio Grande do Norte, considering its potential to promote equity and comprehensiveness in primary care. The research seeks to identify the users' profiles, analyze the barriers and facilitators that influence continuous use of PrEP, and provide recommendations to improve the strategy within Primary Health Care. This is a cross-sectional study with a quantitative approach, in which data will be collected in two stages: analysis of electronic medical records to gather sociodemographic and clinical data, and application of a semi-structured questionnaire to active PrEP users. Data analysis will include descriptive and inferential statistics, focusing on measuring adherence and retention over time and identifying possible associations between variables. The expected results include strengthening the provision of PrEP in primary care, fostering greater user engagement, reducing unplanned interruptions, and improving HIV prevention strategies. For health professionals and local managers, the findings may support the reorganization of care flows, the improvement of user–provider bonds, and the development of more equitable and effective actions. As a technical product, a final report with evidence-based recommendations will be produced, which may guide the implementation and expansion of PrEP in other public health units within the Brazilian Unified Health System (SUS). In summary, the study aims to contribute to a more effective and sensitive response to the HIV epidemic by strengthening preventive care in the context of Primary Health Care.