Banca de DEFESA: JOAQUIN GONZALEZ ARBILDI

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOAQUIN GONZALEZ ARBILDI
DATE: 09/12/2025
TIME: 09:00
LOCAL: INSTITUTO DO CEREBRO - AUDITORIO
TITLE:

COMMUNICATION THROUGH BREATHING-RELATED BRAIN RHYTHMS

KEY WORDS:

RESPIRATION; GAMMA OSCILLATIONS; OLFACTION; COHERENCE; CROSS-FREQUENCY COUPLING; COMMUNICATION SUBSPACE; EMBODIED COGNITION;

PAGES: 113
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

NEURAL OSCILLATIONS ARE A UBIQUITOUS FEATURE OF BRAIN ACTIVITY, WITH POTENTIAL FUNCTIONS RANGING FROM ORGANIZING SPIKING ACTIVITY INTO MEANINGFUL UNITS TO FACILITATING EFFICIENT INFORMATION TRANSFER ACROSS BRAIN NETWORKS. INCREASING EVIDENCE INDICATES THAT FAST BRAIN OSCILLATIONS ARE OFTEN NESTED WITHIN SLOWER CYCLES GOVERNED BY BODILY RHYTHMS. AMONG THESE, THE BREATHING CYCLE — A FUNDAMENTAL PHYSIOLOGICAL RHYTHM — HAS BEEN SHOWN TO SYNCHRONIZE NEURAL ACTIVITY IN HUMANS AND ACROSS A VARIETY OF MAMMALIAN SPECIES. HOWEVER, THE PRECISE MECHANISMS UNDERLYING BREATHING–BRAIN OSCILLATIONS, AS WELL AS THEIR FUNCTIONAL ROLES IN DIFFERENT BRAIN CIRCUITS, REMAIN TO BE FULLY UNDERSTOOD. THIS THESIS ADDRESSES THESE QUESTIONS BY ANALYZING LOCAL FIELD POTENTIALS AND NEURONAL SPIKING ACTIVITY ACROSS DIVERSE BEHAVIORS, INCLUDING SENSORY SAMPLING AND THE SLEEP–WAKE CYCLE. THE MAIN FINDINGS DEMONSTRATE THAT: (1) BREATHING COUPLES LOCAL AND GLOBAL GAMMA OSCILLATIONS ACROSS SPECIES; (2) BREATHING-DRIVEN GAMMA OSCILLATIONS IN THE PRIMARY OLFACTORY CORTEX EMERGE THROUGH LOCAL FEEDBACK INHIBITION TO SUPPORT ODOR REPRESENTATIONS; AND (3) THE BREATHING CYCLE DIRECTLY MODULATES SPIKE TRANSMISSION WITHIN THE MAIN OLFACTORY PATHWAY. FINALLY, THIS THESIS INTEGRATES THESE FINDINGS TO DISCUSS CURRENT UNDERSTANDING OF BREATHING–BRAIN INTERACTIONS, FOCUSING ON THE EVOLUTIONARY PRESSURES THAT SHAPED THIS RELATIONSHIP.

COMMITTEE MEMBERS:
Externo à Instituição - ANDREAS DRAGUHN
Presidente - 1721223 - ADRIANO BRETANHA LOPES TORT
Interno - 1728817 - CLAUDIO MARCOS TEIXEIRA DE QUEIROZ
Interno - 3086031 - DANIEL YASUMASA TAKAHASHI
Externo à Instituição - VITOR LOPES DOS SANTOS