Banca de DEFESA: NAARA FERRAZ DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : NAARA FERRAZ DOS SANTOS
DATE: 22/07/2025
TIME: 09:00
LOCAL: Videoconferência - Link para acesso: https://meet.google.com/landing?hs=197&authuser=0
TITLE:

Phytochemical Study of Aqueous Extract from Angico (Anadenanthera colubrina (Vell.) Brenan) Seeds with Aedicidal Activity.

KEY WORDS:

Aedes aegypti; Arboviruses; Botanical insecticides; Caatinga; Phytocompounds.

PAGES: 75
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:

The Aedes aegypti mosquito (Diptera: Culicidae) is the main vector of a series of arboviruses, including dengue, Zika, yellow fever and chikungunya, highlighting its relevance to global public health. Given the growing resistance to conventional vector control strategies, especially synthetic insecticides, as well as the environmental impacts resulting from their excessive use, the development of sustainable and effective alternatives has become imperative. In this context, the use of aqueous extracts of the seeds of Anadenanthera colubrina (angico), a legume native to Brazil, appears to be a promising alternative for the larval control of Ae. aegypti. Based on preliminary studies that indicated larvicidal activity of the extract, an in-depth analysis was carried out to identify the compounds responsible for such action, using liquid chromatography coupled to mass spectrometry. Six major biomolecules were identified and annotated: pakimic acid, β-sitosterol, sitostanol, bufotenin, anadanthoside and anadanthoflavone. Pakimic acid demonstrates the ability to compromise cell division and larval development; β-sitosterol and sitostanol have the potential to interfere with the mosquito's nervous system by acting on the enzyme acetylcholinesterase; bufotenin shows the possibility of interacting with serotonin receptors, impacting the morphology and motor development of the vector; anadanthoside can inhibit chorion peroxidase, an enzyme essential for egg hardening, compromising the viability of the offspring; and anadanthoflavone acts as a lipoxygenase inhibitor, affecting the process of modulation of the cellular immune response, post-embryonic development and mosquito reproduction. The identification of these biomolecules and the understanding of their likely molecular targets strengthen the hypothesis of an efficient larvicidal action with multiple mechanisms, offering a safer, biodegradable and less harmful alternative to the environment and humans compared to synthetic insecticides. Thus, the present study constitutes a fundamental step in the development of innovative natural larvicides, capable of contributing significantly to the control of Ae. aegypti populations and, consequently, to the mitigation of associated arboviroses.

COMMITTEE MEMBERS:
Presidente - 1549705 - ADRIANA FERREIRA UCHOA
Interno - ***.121.724-** - LUDOVICO MIGLIOLO - UCDB
Externa à Instituição - PATRÍCIA MARIA GUEDES PAIVA - UFPE