Banca de QUALIFICAÇÃO: MYCHELLE KYTCHIA RODRIGUES NUNES DUARTE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MYCHELLE KYTCHIA RODRIGUES NUNES DUARTE
DATE: 28/09/2023
TIME: 09:00
LOCAL: Sala 7 do Departamento de Nutrição - UFRN
TITLE:

The SNP rs17300539, rs1801282, and rs4880 are related to overweight and obesity in a preliminary study in the Brazilian population

KEY WORDS:

Polymorphisms, obesity risk, nutrigenetics, personalized nutrition, direct-to-consumer testing

PAGES: 71
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:

Background: Obesity is a multifactorial, chronic disease increasing worldwide and in Brazil. This disease can be triggered by genetics and environmental factors. The modulation of gene expression by single nucleotide polymorphisms (SNPs) in metabolic pathways is described to impact positively or negatively obesity risk. Thus, an effort has been made to evaluate these SNPs in the population and use it in counseling. The study aimed to investigate the relationship between obesity and 29 SNPs in a preliminary study on Brazilian population. Methods: The relationship at frequency of 29 polymorphisms with body mass index (BMI) was evaluated at 112 individuals. Regression logistic for sex, age, and BMI was used to compare healthy weight (HW) (BMI<25 Kg/m²) versus overweight and obese (OOG) (BMI≥ 25 Kg/m²). Results: The population was mainly men (70%) with a median age of 44y at OOG. The genes ADIPOQ, PPARG, and SOD were statistically associated with BMI. Conclusion: Three among twenty-nine SNPs are related to overweight and obesity in a preliminary study in the Brazilian population The rs17300539 and rs1801282 are associated with obesity risk, and rs4880 with protection. More research is crucial to complete an assessment using the most current genomic methods and lifestyle surveys.

COMMITTEE MEMBERS:
Presidente - 2578619 - ANA HELONEIDA DE ARAUJO MORAIS
Interna - 1674709 - VIVIANE SOUZA DO AMARAL
Externa ao Programa - 2549958 - LUCIA LEITE LAIS - UFRN